Su Qian, Sun Huizhen, Mei Ling, Yan Ying, Ji Huimin, Chang Le, Wang Lunan
National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, Beijing, P.R. China.
Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P.R. China.
Cell Biosci. 2024 Nov 1;14(1):133. doi: 10.1186/s13578-024-01316-3.
Ribosomal proteins (RPs) are essential components of ribosomes, playing a role not only in ribosome biosynthesis, but also in various extra-ribosomal functions, some of which are implicated in the development of different types of tumors. As universally acknowledged, hepatocellular carcinoma (HCC) has been garnering global attention due to its complex pathogenesis and challenging treatments. In this review, we analyze the biological characteristics of RPs and emphasize their essential roles in HCC. In addition to regulating related signaling pathways such as the p53 pathway, RPs also act in proliferation and metastasis by influencing cell cycle, apoptosis, angiogenesis, and epithelial-to-mesenchymal transition in HCC. RPs are expected to unfold new possibilities for precise diagnosis and individualized treatment of HCC.
核糖体蛋白（RPs）是核糖体的重要组成部分，不仅在核糖体生物合成中发挥作用，还参与多种核糖体之外的功能，其中一些功能与不同类型肿瘤的发生发展有关。众所周知，肝细胞癌（HCC）因其复杂的发病机制和具有挑战性的治疗方法而受到全球关注。在本综述中，我们分析了核糖体蛋白的生物学特性，并强调了它们在肝癌中的重要作用。除了调节相关信号通路如p53通路外，核糖体蛋白还通过影响肝癌细胞的细胞周期、凋亡、血管生成和上皮-间质转化，在肝癌的增殖和转移中发挥作用。核糖体蛋白有望为肝癌的精确诊断和个体化治疗开辟新的可能性。
