Is the adenoma-carcinoma sequence contradicted by the differing location of colorectal adenomas and carcinomas?

This article takes a look at the different localisation of colorectal adenomas and carcinomas. The risk of malignancy of 4,257 adenomas found in 1742 patients was determined, and the lesions grouped in accordance with various criteria and risk classes. It was found that the distribution of adenoma locations approximated all the more closely to the distribution pattern of carcinoma sites, the higher the malignancy risk of an adenoma group was. The statistical approximation of adenoma and carcinoma localisations as a function of increasing risk of malignancy must be considered an argument in support of the adenoma--carcinoma sequence.