Eide T J
Histopathology. 1986 Feb;10(2):111-8. doi: 10.1111/j.1365-2559.1986.tb02467.x.
The presence of adenomas in 164 surgical specimens of the large intestine from 81 males and 83 females with colorectal carcinomas was compared with the presence of adenomas in a general necropsy population in northern Norway. In the group of patients with colorectal carcinomas the observed prevalence of single or multiple adenomas was 5.9 times higher than expected from the prevalence in the general necropsy population. The observed-to-expected ratios of all adenomas (4.7), adenomas with villous elements (4.6), adenomas with moderate or severe grades of dysplasia (4.9) and adenomas 10 mm or larger (5.5) were also higher in the surgical series. The study indicates that factors which initiate the growth of adenomas and, to a minor degree, factors which promote the growth of adenomas to a large size are more prevalent in individuals with colorectal carcinoma than in the necropsy population. Factors determining the presence of villous elements and the grades of dysplasia of adenomas seem to operate similarly in adenoma-bearing patients with and without colorectal carcinoma.
对81名男性和83名女性结直肠癌患者的164份大肠手术标本中的腺瘤情况，与挪威北部普通尸检人群中的腺瘤情况进行了比较。在结直肠癌患者组中，观察到的单发或多发腺瘤患病率比普通尸检人群中的预期患病率高5.9倍。手术系列中所有腺瘤（4.7）、有绒毛成分的腺瘤（4.6）、中重度发育异常的腺瘤（4.9）以及直径10毫米或更大的腺瘤（5.5）的观察值与预期值之比也更高。该研究表明，引发腺瘤生长的因素以及在较小程度上促使腺瘤生长至较大尺寸的因素，在结直肠癌患者中比在尸检人群中更为普遍。决定腺瘤绒毛成分的存在和发育异常程度的因素，在有和没有结直肠癌的腺瘤患者中似乎作用相似。
