City Hospital of Ankara, Neurology Department, Ankara, Turkey.
City Hospital of Ankara, Ophthalmology Department, Ankara, Turkey.
Arq Neuropsiquiatr. 2024 Nov;82(11):1-7. doi: 10.1055/s-0044-1791658. Epub 2024 Nov 3.
Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.
To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).
The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.
The lowest total hippocampal volume ( < 0.05) was in the AD group, which was 6.14 ± 0.66 mm, while in the control group, it was 7.7 ± 9.65 mm, and 6.69 ± 0.46 mm in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; < 0.05).
The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.
阿尔茨海默病（AD）是痴呆症最常见的病因，影响着全球很大一部分老年人群。
分析 AD 和轻度认知障碍（MCI）患者的视盘筛板厚度（LCT）与海马体积之间的关系。
本研究的样本包括 20 名近期确诊的 MCI 患者、20 名近期确诊的 AD 患者和 20 名匹配的健康志愿者。每位患者均进行磁共振成像（MRI）扫描。使用 VolBrain 软件（用于 MRI 脑分析的开放获取平台）计算海马体积。进行光学相干断层扫描以测量 LCT。采用方差分析和 Pearson 卡方检验进行结果评估。
AD 组的总海马体体积最低（ < 0.05），为 6.14 ± 0.66 mm，而对照组为 7.7 ± 9.65 mm，MCI 组为 6.69 ± 0.46 mm。与其他组相比，AD 组的 LCT 最薄（202.17 ± 16.35 µm）。根据整个研究人群的结果，低海马体体积导致低 LCT，两者之间存在重要关系（r：0.41； < 0.05）。
目前的研究结果为 AD 和 MCI 患者的海马体体积与 LCT 之间的关系提供了证据。
