Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, China.
Henan Medical Key Laboratory for Research of Trauma and Orthopedics, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Commun Biol. 2024 Nov 3;7(1):1429. doi: 10.1038/s42003-024-07151-z.
Victims of explosive events frequently suffer from blast lung injuries. Immune system has been implicated in the pathogenesis of this disease. However, systemic immune responses underlying the progression and recovery of injury repair remain poorly understood. Here, we depict the systemic landscape of immune dysregulation during blast lung injury and uncover immune recovery patterns. Single-cell analyses reveal dramatic changes in neutrophils, macrophages, monocytes, dendritic cells, and eosinophils after a gas explosion, along with early involvement of CD4 T, CD8 T, and Th17 cells. We demonstrate that myeloid cells primarily exert functions during the acute phase, while the spleen serves as an alternative source of granulocytes. Granulopoiesis is initiated in the bone marrow at a later stage during blast lung injury recovery, rather than at the acute stage. These findings contribute to a better understanding of the pathogenesis and provide valuable insights for potential immune interventions in blast lung injury.
爆炸事件的受害者常患有爆震性肺损伤。免疫系统被认为与这种疾病的发病机制有关。然而，损伤修复的进展和恢复所涉及的全身免疫反应仍知之甚少。在这里，我们描述了爆震性肺损伤过程中免疫失调的全身情况，并揭示了免疫恢复模式。单细胞分析显示，气体爆炸后中性粒细胞、巨噬细胞、单核细胞、树突状细胞和嗜酸性粒细胞发生剧烈变化，同时早期涉及 CD4 T、CD8 T 和 Th17 细胞。我们证明，髓样细胞主要在急性期发挥作用，而脾脏则是粒细胞的另一个来源。在爆震性肺损伤恢复的后期阶段，而非急性期，骨髓中开始粒细胞生成。这些发现有助于更好地了解发病机制，并为爆震性肺损伤的潜在免疫干预提供有价值的见解。
