Kassie Bantamlak Birlie, Getahun Muluken Jemberie, Azanaw Aklilu, Ferede Bayu Teshome, Tassew Dehenenet Flatie
Textile Faculty, Ethiopian Institute of Textile and Fashion Technology, Bahir Dar University, Bahir Dar, P.O. Box 1037, Ethiopia; Medical Textile Research Center, Ethiopian Institute of Textile and Fashion Technology, Bahir Dar University, Bahir Dar, P.O. Box 1037, Ethiopia.
Hawassa University, Institute of Technology, Hawassa, Ethiopia.
Int J Biol Macromol. 2024 Dec;282(Pt 3):136949. doi: 10.1016/j.ijbiomac.2024.136949. Epub 2024 Oct 28.
The increasing demand for sustainable and effective materials in biomedical and personal hygiene applications has driven the exploration of cellulose nanocrystals (CNCs) derived from biomass. These nanomaterials are highly valued for their exceptional mechanical properties, biocompatibility, and renewable nature. Researchers are exploring CNCs for advancing medical and hygiene products, but surface modification is often needed to maximize their benefits. Techniques such as chemical functionalization, physical coating, and hybridization can significantly enhance CNCs dispersibility, stability, and interaction with biological systems. This versatility makes CNCs suitable for a variety of applications, including drug delivery systems, wound dressings, and personal hygiene products. Despite their advantages, maintaining the inherent properties of CNCs while integrating new functionalities through modification poses a challenge. Understanding the impact of various modification techniques on CNC performance is crucial for optimizing their effectiveness. This review aimed to consolidate current knowledge on the surface modification of biomass-derived CNCs, offering insights into different methods and their implications for biomedical and personal hygiene applications. By highlighting advancements, challenges, and prospects, it served as a crucial resource for advancing the development and application of CNCs in these critical fields.
生物医学和个人卫生应用中对可持续且有效的材料的需求不断增加，推动了对源自生物质的纤维素纳米晶体（CNCs）的探索。这些纳米材料因其卓越的机械性能、生物相容性和可再生性而备受重视。研究人员正在探索将CNCs用于改进医疗和卫生产品，但通常需要进行表面改性以最大化其益处。化学功能化、物理涂层和杂交等技术可显著提高CNCs的分散性、稳定性以及与生物系统的相互作用。这种多功能性使CNCs适用于多种应用，包括药物递送系统、伤口敷料和个人卫生产品。尽管它们具有优势，但在通过改性整合新功能的同时保持CNCs的固有特性仍面临挑战。了解各种改性技术对CNC性能的影响对于优化其有效性至关重要。本综述旨在整合有关源自生物质的CNCs表面改性的当前知识，深入了解不同方法及其对生物医学和个人卫生应用的影响。通过突出进展、挑战和前景，它为推进CNCs在这些关键领域的开发和应用提供了重要资源。
