Ellakwa Doha El-Sayed, Rashed Laila Ahmed, Ali Ola Sayed, El-Sabbagh Noha Amr
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Sinai University, Kantra branch, Ismailia, Egypt.
Future Sci OA. 2025 Dec;11(1):2458434. doi: 10.1080/20565623.2025.2458434. Epub 2025 Jan 31.
Alzheimer's disease is a developing public health concern in aging communities that affects a sizable section of the global population. The risk of Alzheimer's disease increases with age; it affects one-third of males and two-thirds of women This research attempts to assess the effect of nano-selenium and thymoquinone on Nrf2 gene expression levels in Alzheimer's disease (AD).
There were five identical groups of 50 albino male rats: a control group that was healthy; an AD positive control group; an AD group that received nano-selenium (5 mg/kg); an AD group that received thymoquinone (2 mg/kg); and an AD group that received both. The duration of treatment was 4 weeks. The levels of Nrf2 in brain tissues were evaluated using real-time PCR.
Nrf2 mean expression levels in the nano-selenium-treated rats, the thymoquinone-treated rats, and the rats that were given both treatments all increased significantly compared to AD rats with no treatment.
This study showed that nano-selenium and thymoquinone elevated Nrf2 gene expression levels in AD.
阿尔茨海默病是老龄化社区中日益受到关注的公共卫生问题，影响着全球相当一部分人口。阿尔茨海默病的风险随年龄增长而增加；它影响三分之一的男性和三分之二的女性。本研究试图评估纳米硒和百里醌对阿尔茨海默病（AD）中Nrf2基因表达水平的影响。
将50只白化雄性大鼠分为五组，每组情况相同：一个健康的对照组；一个AD阳性对照组；一个接受纳米硒（5毫克/千克）的AD组；一个接受百里醌（2毫克/千克）的AD组；以及一个同时接受两者的AD组。治疗持续时间为4周。使用实时PCR评估脑组织中Nrf2的水平。
与未接受治疗的AD大鼠相比，接受纳米硒治疗的大鼠、接受百里醌治疗的大鼠以及同时接受两种治疗的大鼠中Nrf2的平均表达水平均显著升高。
本研究表明，纳米硒和百里醌可提高AD中Nrf2基因的表达水平。
