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绿茶提取物作为下颌磨牙拔除后局部止血剂的临床效果。

Clinical Effectiveness of Green Tea Extracts as a Local Haemostatic Agent Following Mandibular Molar Extraction.

机构信息

Department of Oral and Maxillofacial Surgery, College of Dentistry, King Khalid University, Abha, Saudi Arabia.

Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.

出版信息

J Coll Physicians Surg Pak. 2024 Nov;34(11):1281-1286. doi: 10.29271/jcpsp.2024.11.1281.

Abstract

OBJECTIVE

To determine the clinical effectiveness of different green tea extracts (GTEs) in reducing bleeding after extraction of mandibular molars.

STUDY DESIGN

Randomised controlled trial. Place and Duration of the Study: College of Dentistry, King Khalid University, Abha, Saudi Arabia, from October to December 2022.

METHODOLOGY

A total of 64 patients were selected from those who attended dental clinics at the College of Dentistry, King Khalid University for extraction of their mandibular molars. They were equally and randomly divided into a control and three test groups by asking the patient to choose a numbered piece of paper. In the first group, normal saline-soaked sterile gauze was used after the tooth extraction while in the three test groups, different GTEs (methanolic GTE, aqueous GTE, and tannin isolated from the green tea) were applied. Monitoring of the bleeding by observing the extraction socket was carried out at regular intervals of five minutes until the oozing subsided, and then once an hour after that.

RESULTS

Each group had 16 patients. The mean of bleeding stop-minutes was significantly different among the groups (61.56 minutes for the control group, 7.50 minutes 8.44 minutes and 5.62 minutes for the test groups, p <0.001). The median of bleeding stop-minutes of the control group was significantly higher than all test groups (p <0.001). The number of patients in whom bleeding was continued one hour after surgery was significantly higher in the control group (p = 0.005). Moreover, tannin has the greatest haemostatic effect compared to aqueous and methanolic GTEs.

CONCLUSION

Significant haemostatic effect has been shown by all GTEs. Tannin isolated from green tea has shown a significantly higher haemostatic effect than to the aqueous and methanolic extracts.

KEY WORDS

Bleeding, Green tea extracts, Haemostasis, Tannin isolate, Molar extraction.

摘要

目的

评估不同绿茶提取物(GTE)在减少下颌磨牙拔除后出血方面的临床疗效。

研究设计

随机对照试验。

地点和研究时间

沙特阿拉伯阿巴哈的哈利德国王大学牙科学院,2022 年 10 月至 12 月。

方法

从到哈利德国王大学牙科学院牙科诊所就诊的患者中选择了 64 名患者,这些患者需要拔除下颌磨牙。通过让患者选择一张标有数字的纸,将他们平均且随机分为对照组和三组实验组。在第一组中,拔牙后使用生理盐水浸泡的无菌纱布;在三组实验组中,分别使用不同的 GTE(甲醇 GTE、水 GTE 和从绿茶中分离出的单宁)。通过观察拔牙窝来定期监测出血情况,每隔五分钟监测一次,直到渗血停止,然后每小时监测一次。

结果

每组有 16 名患者。组间出血停止时间的平均值差异有统计学意义(对照组为 61.56 分钟,实验组分别为 7.50 分钟、8.44 分钟和 5.62 分钟,p <0.001)。对照组的出血停止时间中位数明显高于所有实验组(p <0.001)。手术后一小时仍持续出血的患者数量在对照组中明显更高(p = 0.005)。此外,单宁与水和甲醇 GTE 相比具有更大的止血作用。

结论

所有 GTE 均显示出显著的止血效果。从绿茶中分离出的单宁比水和甲醇提取物具有更高的止血效果。

关键词

出血、绿茶提取物、止血、单宁分离物、磨牙拔除。

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