Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
HUN-REN-SU Translational Extracellular Vesicle Research Group, Budapest, Hungary.
Br J Pharmacol. 2024 Dec;181(23):4733-4749. doi: 10.1111/bph.17336. Epub 2024 Sep 20.
In recent years, various approaches have been undertaken to eliminate lipoproteins co-isolated with extracellular vesicles, as they were initially regarded as contaminating entities. However, novel discoveries are reshaping our perspective. In body fluids, these distinct particles not only co-exist, but also interactions between them are likely to occur. Extracellular vesicles and lipoproteins can associate with each other, share cargo, influence each other's functions, and jointly have a role in the pathomechanisms of diseases. Additionally, their association carries important implications for therapeutic and pharmacological aspects of lipid-lowering strategies. Extracellular vesicles and lipoprotein particles may have roles in the elimination of each other from the circulation. The objective of this minireview is to delve into these aspects. Here, we show that under certain physiological and pathological conditions, extracellular vesicles and lipoproteins are 'partners' rather than 'strangers' or 'rivals'.
近年来，人们采取了各种方法来去除与细胞外囊泡共分离的脂蛋白，因为最初它们被认为是污染物质。然而，新的发现正在改变我们的观点。在体液中，这些不同的颗粒不仅共存，而且它们之间很可能发生相互作用。细胞外囊泡和脂蛋白可以相互结合，共享货物，影响彼此的功能，并共同参与疾病的病理机制。此外，它们的结合对降脂策略的治疗和药理学方面具有重要意义。细胞外囊泡和脂蛋白颗粒在从循环中消除彼此方面可能具有作用。这篇综述的目的是深入探讨这些方面。在这里，我们表明，在某些生理和病理条件下，细胞外囊泡和脂蛋白是“伙伴”，而不是“陌生人”或“竞争对手”。
