Lee Sun Young, Klingeborn Mikael, Bulte Jeff W M, Chiu Daniel T, Chopp Michael, Cutler Christopher W, Das Saumya, Egwuagu Charles E, Fowler Christie D, Hamm-Alvarez Sarah F, Lee Hakho, Liu Yutao, Mead Ben, Moore Tara L, Ravindran Sriram, Shetty Ashok K, Skog Johan, Witwer Kenneth W, Djalilian Ali R, Weaver Alissa M
Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
McLaughlin Research Institute, Great Falls, Montana, USA.
J Extracell Vesicles. 2024 Dec;13(12):e70023. doi: 10.1002/jev2.70023.
With an evolving understanding and new discoveries in extracellular vesicle (EV) biology and their implications in health and disease, the significant diagnostic and therapeutic potential of EVs for vision research has gained recognition. In 2021, the National Eye Institute (NEI) unveiled its Strategic Plan titled 'Vision for the Future (2021-2025),' which listed EV research as a priority within the domain of Regenerative Medicine, a pivotal area outlined in the Plan. In alignment with this prioritization, NEI organized a workshop inviting twenty experts from within and beyond the visual system. The workshop aimed to review current knowledge in EV research and explore gaps, needs and opportunities for EV research in the eye, including EV biology and applications of EVs in diagnosis, therapy and prognosis within the visual system. This perspective encapsulates the workshop's deliberations, highlighting the current landscape and potential implications of EV research in advancing eye health and addressing visual diseases.
随着对细胞外囊泡（EV）生物学的理解不断发展以及新发现不断涌现，及其对健康和疾病的影响，EV在视觉研究中具有的重大诊断和治疗潜力已得到认可。2021年，美国国立眼科研究所（NEI）公布了其题为《未来愿景（2021 - 2025）》的战略计划，该计划将EV研究列为再生医学领域的优先事项，再生医学是该计划中概述的一个关键领域。与此优先事项相一致，NEI组织了一次研讨会，邀请了来自视觉系统内外的二十位专家。该研讨会旨在回顾EV研究的当前知识，并探索眼部EV研究的差距、需求和机会，包括EV生物学以及EV在视觉系统诊断、治疗和预后方面的应用。这一观点总结了研讨会的讨论内容，突出了EV研究在促进眼部健康和解决视觉疾病方面的当前状况及潜在影响。
