David L, Salle B, Chopard P, Grafmeyer D
Helv Paediatr Acta. 1977 Jun;32(1):39-48.
Serum immunoreactive calcitonin (iCT), serum immunoreactive parathyroid hormone (iPTH) and serum Ca, Mg, P and total protein levels were determined sequentially at 5 given periods of time from 1 to 48 h of age in 16 low birth weight infants. Mean +/- SD serum Ca levels decreased from 8.99 +/- 0.79 mg/100 ml at time 1--2 h to 7.00 +/- 0.51 mg/100 ml at time 12--14 h; there was a small further decrease at time 22--26 h: 6.79 +/- 1.07 mg/100 ml. There was no significant change in serum Mg, P or total protein during the same periods of time. Serum iPTH levels increased steadily from time 1--2 h to time 44--48 h reaching above normal range values. Serum iCT levels were non detectable (less than 150 pg/ml) in 11 among 15 infants at time 1--2 h. A marked increase in mean +/- SD serum iCT levels was observed at time 12--14 h (1850 +/- 872 pg/ml) and time 22--26 h (1462 +/- 806 pg/ml) followed by a decrease at time 44--48 h. A negative correlation was found between serum iCT levels and respectively gestational age (p less than 0.01) and serum Ca levels (p less than 0.01) at time 22--26 h while serum iCT levels correlated positively with serum iPTH levels (p less than 0.05). Evidence obtained from this study indicates that a secretion of calcitonin takes place during the early neonatal period in low birth weight infants and that this secretion is a contributing factor of the socalled "early-type" neonatal hypocalcemia.
对16名低体重儿在出生后1至48小时内的5个特定时间段，依次测定其血清免疫反应性降钙素（iCT）、血清免疫反应性甲状旁腺激素（iPTH）以及血清钙、镁、磷和总蛋白水平。血清钙水平的均值±标准差从1 - 2小时时的8.99±0.79mg/100ml降至12 - 14小时时的7.00±0.51mg/100ml；在22 - 26小时时又有小幅下降：6.79±1.07mg/100ml。在相同时间段内，血清镁、磷或总蛋白水平无显著变化。血清iPTH水平从1 - 2小时到44 - 48小时稳步上升，达到高于正常范围的值。15名婴儿中有11名在1 - 2小时时血清iCT水平不可检测（低于150pg/ml）。在12 - 14小时（1850±872pg/ml）和22 - 26小时（1462±806pg/ml）观察到血清iCT水平的均值±标准差显著升高，随后在44 - 48小时下降。在22 - 26小时时，血清iCT水平与胎龄（p＜0.01）和血清钙水平（p＜0.01）呈负相关，而血清iCT水平与血清iPTH水平呈正相关（p＜0.05）。本研究获得的证据表明，低体重儿在新生儿早期会发生降钙素分泌，且这种分泌是所谓“早期型”新生儿低钙血症的一个促成因素。
