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癫痫发作与癫痫:英国医学生概述

Seizures and Epilepsy: An Overview for UK Medical Students.

作者信息

Ahmed Abdullah, Rahman Abdul-Habib, Williams Shimul, Toufiq Mubeen, Jamileh Eyad, Chaudhry Sheema, Ahmed Khadijah, Ahmed Munir

机构信息

Family Medicine, Whipps Cross Hospital, London, GBR.

Cardiology, Luton and Dunstable Hospital, Luton, GBR.

出版信息

Cureus. 2024 Oct 1;16(10):e70654. doi: 10.7759/cureus.70654. eCollection 2024 Oct.

Abstract

Epilepsy is a common neurological disorder impacting millions globally, marked by recurrent, unprovoked seizures. This review article, tailored for UK medical students, provides a broad clinical overview of epilepsy, focusing on its pathophysiology, classification, and management strategies. The article clarifies the distinction between epilepsy and seizures and delves into key areas, including risk factors, clinical features, and differential diagnosis. The discussion extends to diagnostic methods, underscoring the importance of conducting a thorough evaluation in diagnosing and managing epilepsy effectively. Data were drawn from the UK National Institute for Health and Care Excellence (NICE) guidelines, World Health Organization (WHO) reports, and key peer-reviewed studies. Particular attention was given to UK-specific data on epilepsy incidence, treatment gaps, and clinical outcomes. A review of relevant literature was conducted, covering epidemiology, pathophysiology, diagnostic protocols, and management strategies based on UK practices. Finally, the article addresses the acute management of seizures and the pharmacological and non-pharmacological management of epilepsy based on the NICE guidelines. The goal is to offer medical students a concise yet comprehensive understanding of epilepsy, preparing them for practical, evidence-based decision-making in clinical practice.

摘要

癫痫是一种常见的神经系统疾病,全球数百万人受其影响,其特征为反复发作且无诱因的癫痫发作。这篇为英国医学生量身定制的综述文章,对癫痫进行了广泛的临床概述,重点关注其病理生理学、分类及管理策略。文章阐明了癫痫与癫痫发作之间的区别,并深入探讨了关键领域,包括危险因素、临床特征及鉴别诊断。讨论还延伸至诊断方法,强调了在有效诊断和管理癫痫中进行全面评估的重要性。数据来源于英国国家卫生与临床优化研究所(NICE)指南、世界卫生组织(WHO)报告以及同行评审的关键研究。特别关注了英国关于癫痫发病率、治疗差距及临床结果的特定数据。对相关文献进行了综述,涵盖基于英国实践的流行病学、病理生理学、诊断方案及管理策略。最后,文章根据NICE指南阐述了癫痫发作的急性处理以及癫痫的药物和非药物管理方法。目的是为医学生提供对癫痫简洁而全面的理解,使他们为临床实践中基于证据的实际决策做好准备。

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