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Phytochemical and Pharmacological Aspects of Psoralen - A Bioactive Furanocoumarin from Psoralea corylifolia Linn.补骨脂素的植物化学和药理学方面：来自补骨脂 Psoralea corylifolia Linn 的一种生物活性呋喃香豆素
Chem Biodivers. 2023 Nov;20(11):e202300867. doi: 10.1002/cbdv.202300867. Epub 2023 Oct 19.
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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin.光老化：紫外线辐射诱导的炎症和免疫抑制加速皮肤的衰老过程。
Inflamm Res. 2022 Aug;71(7-8):817-831. doi: 10.1007/s00011-022-01598-8. Epub 2022 Jun 24.
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ROS generation is involved in titanium dioxide nanoparticle-induced AP-1 activation through p38 MAPK and ERK pathways in JB6 cells.活性氧簇的产生与二氧化钛纳米颗粒诱导 JB6 细胞中 AP-1 激活有关，其涉及 p38MAPK 和 ERK 通路。
Environ Toxicol. 2022 Feb;37(2):237-244. doi: 10.1002/tox.23393. Epub 2021 Nov 3.
4
Isopimpinellin extends antiangiogenic effect through overexpression of miR-15b-5p and downregulating angiogenic stimulators.异土木香内酯通过过表达 miR-15b-5p 和下调血管生成刺激物来延长抗血管生成作用。
Mol Biol Rep. 2022 Jan;49(1):279-291. doi: 10.1007/s11033-021-06870-4. Epub 2021 Oct 28.
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Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging.与紫外线辐射介导的皮肤衰老相关的炎症分子。
Int J Mol Sci. 2021 Apr 12;22(8):3974. doi: 10.3390/ijms22083974.
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Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts.Bach2调节自噬以调节紫外线A诱导的皮肤成纤维细胞光老化。
Free Radic Biol Med. 2021 Jun;169:304-316. doi: 10.1016/j.freeradbiomed.2021.04.003. Epub 2021 Apr 18.
7
Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects.呋喃香豆素的抗癌潜力：机制和治疗方面。
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异茴芹素通过抑制人皮肤成纤维细胞中的MAPK/AP-1信号通路来抑制UVA诱导的基质金属蛋白酶过度产生。

Isopimpinellin inhibits UVA-induced overproduction of MMPs via suppression of MAPK/AP-1 signaling in human dermal fibroblasts.

作者信息

Oh Jung Hwan, Karadeniz Fatih, Seo Youngwan, Kong Chang-Suk

机构信息

Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University, Busan, 46958 Republic of Korea.

Nutritional Education, Graduate School of Education, Silla University, Busan, 46958 Republic of Korea.

出版信息

Food Sci Biotechnol. 2024 Jul 24;33(15):3579-3589. doi: 10.1007/s10068-024-01611-2. eCollection 2024 Dec.

DOI:10.1007/s10068-024-01611-2
PMID:39493386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11525369/
Abstract

is an edible halophyte and an ingredient in traditional Korean medicine. In the present study, isopimpinellin (IPN), a bioactive coumarin, was isolated from the medicinal halophyte , and the effects of IPN against UVA-induced photoaging were investigated in human dermal fibroblasts. Photoaging is a skin disorder that manifests itself as premature skin aging due to chronic exposure to UV radiation. The symptoms of photoaging mainly arise from degraded skin connective tissue produced by overly expressed matrix metalloproteinases (MMPs). IPN treatment decreased the UVA-induced formation of reactive oxygen species and decreased MMP-1, MMP-3, and MMP-9 collagenases at the protein level. The UVA-mediated suppression of tissue inhibitors of MMP-1 and -2 was attenuated with IPN. The presence of 10 μM IPN inhibited the MAPK-mediated phosphorylation of c-Fos and c-Jun. In conclusion, the overall result of the current study indicated that IPN inhibited the UVA-induced overexpression of MMPs via blocking the MAPK/AP-1 pathway.

摘要

是一种可食用的盐生植物，也是传统韩医的一种成分。在本研究中，从药用盐生植物中分离出生物活性香豆素异茴芹内酯（IPN），并在人皮肤成纤维细胞中研究了IPN对紫外线A（UVA）诱导的光老化的影响。光老化是一种皮肤疾病，由于长期暴露于紫外线辐射而表现为皮肤过早老化。光老化的症状主要源于过度表达的基质金属蛋白酶（MMPs）导致的皮肤结缔组织降解。IPN处理可减少UVA诱导的活性氧生成，并在蛋白质水平上降低MMP-1、MMP-3和MMP-9胶原酶的水平。IPN减弱了UVA介导的对MMP-1和-2组织抑制剂的抑制作用。10μM IPN的存在抑制了丝裂原活化蛋白激酶（MAPK）介导的c-Fos和c-Jun磷酸化。总之，本研究的总体结果表明，IPN通过阻断MAPK/活化蛋白-1（AP-1）途径抑制UVA诱导的MMPs过表达。