Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Jilin Green Food Engineering Research Institute, Changchun 130022, China.
Nutrients. 2021 Jun 2;13(6):1914. doi: 10.3390/nu13061914.
Imbalance of protein homeostasis, with excessive protein degradation compared with protein synthesis, leads to the development of muscle atrophy resulting in a decrease in muscle mass and consequent muscle weakness and disability. Potential triggers of muscle atrophy include inflammation, malnutrition, aging, cancer, and an unhealthy lifestyle such as sedentariness and high fat diet. Nutraceuticals with preventive and therapeutic effects against muscle atrophy have recently received increasing attention since they are potentially more suitable for long-term use. The implementation of nutraceutical intervention might aid in the development and design of precision medicine strategies to reduce the burden of muscle atrophy. In this review, we will summarize the current knowledge on the importance of nutraceuticals in the prevention of skeletal muscle mass loss and recovery of muscle function. We also highlight the cellular and molecular mechanisms of these nutraceuticals and their possible pharmacological use, which is of great importance for the prevention and treatment of muscle atrophy.
蛋白质动态平衡失衡，与蛋白质合成相比，蛋白质降解过度，导致肌肉萎缩的发展，导致肌肉质量减少，进而导致肌肉无力和残疾。肌肉萎缩的潜在触发因素包括炎症、营养不良、衰老、癌症和不健康的生活方式，如久坐不动和高脂肪饮食。具有预防和治疗肌肉萎缩作用的营养保健品最近受到越来越多的关注，因为它们更适合长期使用。营养保健品干预的实施可能有助于制定和设计精准医学策略，以减轻肌肉萎缩的负担。在这篇综述中，我们将总结营养保健品在预防骨骼肌肉质量损失和恢复肌肉功能方面的重要性。我们还强调了这些营养保健品的细胞和分子机制及其可能的药理学用途，这对于预防和治疗肌肉萎缩非常重要。
