Mandolesi Sandro, Niglio Tarcisio, Lenci Chiara
Research Department of the Mediterranean Pole, Technoscience, Science and Technology Park, San Severo, Italy.
Istituto Superiore di Sanità, Roma, Italy.
Med Devices (Auckl). 2024 Oct 29;17:417-426. doi: 10.2147/MDER.S480815. eCollection 2024.
The cerebral fluid-dynamic system plays a critical role in maintaining brain health and function. Recent studies identify the glymphatic system as primarily responsible for removing waste products and toxins from brain tissue. In recent years, we have achieved beneficial improvements in MS patients' symptoms and lifestyle using a specific Fluid Dynamic Intensive MAM (FD-MAM) protocol.
We treated 40 outpatients with progressive MS, aged 45-55 years and with EDSS scores from 6 to 9. We applied FD-MAM in 10 daily sessions over two weeks. Before and after glymphatic drainage by FD-MAM, we assessed each patient's clinical status and quality of life using six validated questionnaires.
Data from the six validated questionnaires administered to the 40 MS patients show an improvement in 83% of the scores. At the same time, we observed a shift from pathological to physiological values in 50% of the pathological scores after 10 sessions of FD-MAM protocol.
This study confirms the positive improvements on life quality in outpatients with progressive multiple sclerosis after one cycle of Fluid Dynamic Intensive MAM (FD-MAM) protocol. Initial follow-up on few patients treated with the FD-MAM protocol suggests that the results persist for six to ten months post-treatment. Future detailed studies, on MS outpatients' larger cohort, are essential to assess the duration of results and its effect on glymphatic system.
脑脊液动力系统在维持大脑健康和功能方面起着关键作用。最近的研究表明，类淋巴系统主要负责清除脑组织中的废物和毒素。近年来，我们使用特定的流体动力学强化MAM（FD-MAM）方案，在改善多发性硬化症（MS）患者的症状和生活方式方面取得了有益的进展。
我们治疗了40名年龄在45至55岁之间、扩展残疾状态量表（EDSS）评分在6至9分的进展型MS门诊患者。我们在两周内进行了10次每日疗程的FD-MAM治疗。在通过FD-MAM进行类淋巴引流之前和之后，我们使用六份经过验证的问卷评估了每位患者的临床状况和生活质量。
对40名MS患者进行的六份经过验证的问卷调查数据显示，83%的评分有所改善。同时，在进行10次FD-MAM方案疗程后，我们观察到50%的病理评分从病理值转变为生理值。
本研究证实了在进行一个周期的流体动力学强化MAM（FD-MAM）方案后，进展型多发性硬化症门诊患者的生活质量有积极改善。对少数接受FD-MAM方案治疗的患者进行的初步随访表明，治疗后结果可持续六至十个月。未来对更大规模MS门诊患者队列进行详细研究，对于评估结果的持续时间及其对类淋巴系统的影响至关重要。
