Department of Medical Biotechnology & Nanotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy.
Pharmacol Res. 2020 Jun;156:104765. doi: 10.1016/j.phrs.2020.104765. Epub 2020 Mar 23.
Curcumin (Cur) is an active derivative extracted from turmeric which exerts a wide range of interactions with biomolecules through complex signaling pathways. Cur has been extensively shown to possess potential antitumor properties. In addition, there is growing body of evidence suggesting that Cur may exert potential anti-estrogen and anti-androgen activity. In vitro and in vivo studies suggest that anticancer properties of Cur against tumors affecting the reproductive system in females and males may be underlied by the Cur-mediated inhibition of androgen and estrogen signaling pathways. In this review we examine various studies assessing the crosstalk between Cur and both androgen and estrogen hormonal activity. Also, we discuss the potential chemopreventive and antitumor role of Cur in the most prevalent cancers affecting the reproductive system in females and males.
姜黄素（Cur）是从姜黄中提取的一种活性衍生物，通过复杂的信号通路与生物分子广泛相互作用。大量研究表明，姜黄素具有潜在的抗肿瘤特性。此外，越来越多的证据表明，姜黄素可能具有潜在的抗雌激素和抗雄激素活性。体外和体内研究表明，姜黄素对女性和男性生殖系统肿瘤的抗癌特性可能是由于姜黄素介导的抑制雄激素和雌激素信号通路所致。在这篇综述中，我们研究了各种评估姜黄素与雄激素和雌激素激素活性之间相互作用的研究。此外，我们还讨论了姜黄素在女性和男性生殖系统最常见癌症中的潜在化学预防和抗肿瘤作用。
