From the Department of Neuroradiology (I.R., N.S., C.Z., J.S.K.)
From the Department of Neuroradiology (I.R., N.S., C.Z., J.S.K.).
AJNR Am J Neuroradiol. 2020 Dec;41(12):2333-2338. doi: 10.3174/ajnr.A6807. Epub 2020 Oct 29.
A 3D T1-weighted black-blood sequence was recently shown to improve the detection of contrast-enhancing lesions in the brain in patients with MS compared with a 3D T1-weighted MPRAGE sequence. We compared a contrast-enhanced 3D T1-weighted black-blood sequence with a dedicated orbital contrast-enhanced T1-weighted Dixon sequence in patients with acute optic neuritis.
MR imaging data (3T) of 51 patients showing symptoms of acute optic neuritis were analyzed retrospectively, including whole-brain contrast-enhanced 3D T1-weighted black-blood and dedicated orbital coronal 2D or 3D contrast-enhanced T1-weighted Dixon sequences. Two neuroradiologists assessed the images for overall image quality, artifacts, diagnostic confidence, and visual contrast enhancement. Furthermore, the standardized contrast-to-noise ratio was calculated. The final diagnosis of acute optic neuritis was established on the basis of clinical presentation, visually evoked potentials, and optical coherence tomography.
Thirty of 51 patients were diagnosed with acute optic neuritis. Of those, 21 showed contrast-enhancing lesions in the optic nerves, similarly detectable on contrast-enhanced T1-weighted Dixon and contrast-enhanced T1-weighted black-blood images. Thus, the accuracy for each sequence was identical, with a resulting sensitivity of 70% and specificity of 90% or 100% (depending on the reader). Overall image quality, diagnostic confidence, visual contrast enhancement, and artifacts were rated similarly in contrast-enhanced 3D T1-weighted black-blood and dedicated orbital contrast-enhanced T1-weighted Dixon sequences. There was no significant difference (= .27) in the mean standardized contrast-to-noise ratio between contrast-enhanced T1-weighted black-blood (1.76 ± 1.07) and contrast-enhanced T1-weighted Dixon (2.29 ± 2.49) sequences.
Contrast-enhanced 3D T1-weighted black-blood imaging is comparable in accuracy and qualitative/quantitative features with dedicated orbital contrast-enhanced T1-weighted Dixon imaging for the detection of acute optic neuritis. Therefore, when used, it has the potential to considerably shorten total patient imaging time.
最近的一项 3D T1 加权黑血序列研究表明，与 3D T1 加权 MPRAGE 序列相比，该序列可提高 MS 患者脑内增强病变的检出率。我们比较了急性视神经炎患者增强的 3D T1 加权黑血序列与专用眼眶增强 T1 加权 Dixon 序列。
回顾性分析了 51 例有急性视神经炎症状患者的磁共振成像（3T）资料，包括全脑增强 3D T1 加权黑血序列和专用眼眶冠状位 2D 或 3D 增强 T1 加权 Dixon 序列。两位神经放射科医生评估了图像的整体图像质量、伪影、诊断信心和视觉对比度增强。此外，还计算了标准化信噪比。根据临床表现、视觉诱发电位和光学相干断层扫描结果确定急性视神经炎的最终诊断。
51 例患者中 30 例被诊断为急性视神经炎。其中 21 例在视神经中显示出增强病变，在增强 T1 加权 Dixon 和增强 T1 加权黑血图像上同样可以检测到。因此，每种序列的准确率相同，灵敏度为 70%，特异度为 90%或 100%（取决于读者）。增强 3D T1 加权黑血序列和专用眼眶增强 T1 加权 Dixon 序列的整体图像质量、诊断信心、视觉对比度增强和伪影的评分相似。增强 T1 加权黑血（1.76±1.07）与增强 T1 加权 Dixon（2.29±2.49）序列的平均标准化信噪比差异无统计学意义（=0.27）。
增强 3D T1 加权黑血成像在检测急性视神经炎的准确性和定性/定量特征方面与专用眼眶增强 T1 加权 Dixon 成像相当。因此，在使用时，它有可能显著缩短患者的总成像时间。
