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甘油衍生的罗伊氏菌素调节人类肠道微生物群和代谢产物。

Glycerol-derived reuterin regulates human intestinal microbiota and metabolites.

作者信息

Yang Xi, Liu Wei, Zhang Xiaoling, Sun Minhua, Yi Hongbo, Liao Shenquan, Xiang Rong, Zhang Hao, Yang Qiao, Mori Hirotada

机构信息

State Key Laboratory of Livestock and Poultry Breeding, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.

Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

出版信息

Front Microbiol. 2024 Oct 18;15:1454408. doi: 10.3389/fmicb.2024.1454408. eCollection 2024.

DOI:10.3389/fmicb.2024.1454408
PMID:39493857
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527728/
Abstract

Reuterin, a mixture of different forms of 3-hydroxypropanal (3-HPA), including HPA hydrate and HPA dimer, is an antimicrobial compound converted from glycerol by . Although its antimicrobial function may be related to its interaction with thiol groups, its temperature stability and effect on the gut environment remain unclear. The present study evaluated the antimicrobial effects and activity of reuterin against and . Utilization of a reliable gut microbiome fermentation system revealed that reuterin has a modulatory effect on the gut microbial community. Reuterin treatment completely inhibited H and NH production in the gut and significantly enhanced the synthesis of branched short-chain fatty acids. 16s rRNA sequencing indicated that reuterin promoted the growth of Proteobacteria and Bacteroidetes in the system and significantly modulated gut microbiota composition.

摘要

罗伊氏菌素是由不同形式的3-羟基丙醛（3-HPA）组成的混合物，包括3-HPA水合物和3-HPA二聚体，它是一种由甘油经……转化而成的抗菌化合物。尽管其抗菌功能可能与其与巯基的相互作用有关，但其温度稳定性及其对肠道环境的影响仍不清楚。本研究评估了罗伊氏菌素对……和……的抗菌作用及活性。利用可靠的肠道微生物群发酵系统发现，罗伊氏菌素对肠道微生物群落具有调节作用。罗伊氏菌素处理完全抑制了肠道中H和NH的产生，并显著增强了支链短链脂肪酸的合成。16s rRNA测序表明，罗伊氏菌素促进了……系统中变形菌门和拟杆菌门的生长，并显著调节了肠道微生物群的组成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/9f77fd67f756/fmicb-15-1454408-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/d0c93138f2e8/fmicb-15-1454408-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/06d389c8dc71/fmicb-15-1454408-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/e4e431926c02/fmicb-15-1454408-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/7eedeb827c11/fmicb-15-1454408-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/41ff3e4f15d2/fmicb-15-1454408-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/9f77fd67f756/fmicb-15-1454408-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/d0c93138f2e8/fmicb-15-1454408-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/06d389c8dc71/fmicb-15-1454408-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/e4e431926c02/fmicb-15-1454408-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/7eedeb827c11/fmicb-15-1454408-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/41ff3e4f15d2/fmicb-15-1454408-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3ea/11527728/9f77fd67f756/fmicb-15-1454408-g006.jpg

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本文引用的文献

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Foods. 2022 Dec 10;11(24):4000. doi: 10.3390/foods11244000.
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Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance.雷替曲塞在健康的肠道微生物群中通过改变氧化还原平衡抑制结直肠癌生长。
Cancer Cell. 2022 Feb 14;40(2):185-200.e6. doi: 10.1016/j.ccell.2021.12.001. Epub 2021 Dec 23.
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Inhibitory Activity of Natural Synergetic Antimicrobial Consortia Against on Broiler Chicken Carcasses.
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Front Microbiol. 2021 Apr 29;12:656956. doi: 10.3389/fmicb.2021.656956. eCollection 2021.
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Reuterin disrupts metabolism and pathogenicity through reactive oxygen species generation.雷替曲塞通过活性氧的生成来破坏新陈代谢和致病性。
Gut Microbes. 2020 Nov 9;12(1):1788898. doi: 10.1080/19490976.2020.1795388.
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The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome.益生菌对人类肠道微生物组产生短链脂肪酸的影响。
Nutrients. 2020 Apr 16;12(4):1107. doi: 10.3390/nu12041107.
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