National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Department of Dermatology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China.
Int J Biol Sci. 2024 Oct 7;20(14):5436-5449. doi: 10.7150/ijbs.102445. eCollection 2024.
Autoimmune diseases and cancers, two seemingly unrelated diseases, have been threatening human health, and many of them have no cure. By identifying pathological inflammation as the driving cause of uncontrolled cell proliferation in both classes of diseases, and differentiating autoimmune disorders and cancers by whether the cell death programs are under control, we propose the attenuation of prolonged inflammation via maintaining mitochondrial reduction-oxidation (redox) homeostasis being a possible cure of both diseases. Importantly, we propose the feasibility of applying cold atmospheric plasma (CAP) in treating autoimmune disorders and cancers given its redox-modulatory nature, which not only extends the medical utilities of CAP to autoimmune diseases and all other inflammation-driven disorders, but also positions the efficacy of CAP against cancer cells to its suppressive role on prolonged inflammation. Our insights may open an innovative avenue towards a unified view on the molecular mechanism driving the diversified types of medical miracles of CAP and what CAP can do in the field of plasma medicine.
自身免疫性疾病和癌症，这两种看似不相关的疾病，一直威胁着人类的健康，而且很多疾病都无法治愈。通过将病理性炎症确定为这两类疾病中不受控制的细胞增殖的驱动因素，并通过细胞死亡程序是否受到控制来区分自身免疫性疾病和癌症，我们提出通过维持线粒体氧化还原（redox）平衡来减弱长期炎症可能是这两种疾病的一种治疗方法。重要的是，鉴于其氧化还原调节特性，我们提出了应用冷等离体（CAP）治疗自身免疫性疾病和癌症的可行性，这不仅将 CAP 的医疗用途扩展到自身免疫性疾病和所有其他炎症驱动的疾病，还将 CAP 对癌细胞的疗效与其对长期炎症的抑制作用联系起来。我们的研究结果可能为 CAP 多样化的医学奇迹的分子机制以及 CAP 在等离子医学领域的作用提供一个新的研究思路。
