等离子体医学：应用氧化还原生物学领域。
Plasma Medicine: A Field of Applied Redox Biology.
机构信息
Leibniz Institute for Plasma Science and Technology, INP Greifswald, Greifswald, Germany
Greifswald University Medicine, Greifswald, Germany.
出版信息
In Vivo. 2019 Jul-Aug;33(4):1011-1026. doi: 10.21873/invivo.11570.
Abstract
Plasma medicine comprises the application of physical plasma directly on or in the human body for therapeutic purposes. Three most important basic plasma effects are relevant for medical applications: i) inactivation of a broad spectrum of microorganisms, including multidrug-resistant pathogens, ii) stimulation of cell proliferation and angiogenesis with lower plasma treatment intensity, and iii) inactivation of cells by initialization of cell death with higher plasma treatment intensity, above all in cancer cells. Based on own published results as well as on monitoring of relevant literature the aim of this topical review is to summarize the state of the art in plasma medicine and connect it to redox biology. One of the most important results of basic research in plasma medicine is the insight that biological plasma effects are mainly mediated via reactive oxygen and nitrogen species influencing cellular redox-regulated processes. Plasma medicine can be considered a field of applied redox biology.
摘要
等离子体医学包括直接将物理等离子体应用于人体或人体内部，以达到治疗目的。有三种最重要的基本等离子体效应与医学应用相关：i）广谱微生物（包括多药耐药病原体）的失活，ii）在较低的等离子体处理强度下刺激细胞增殖和血管生成，以及 iii）在较高的等离子体处理强度下通过引发细胞死亡来失活细胞，尤其是癌细胞。基于我们自己已发表的结果以及对相关文献的监测，本专题综述的目的是总结等离子体医学的最新技术，并将其与氧化还原生物学联系起来。等离子体医学基础研究的最重要结果之一是认识到，生物等离子体效应主要是通过活性氧和氮物种影响细胞氧化还原调节过程来介导的。因此，可以将等离子体医学视为应用氧化还原生物学的一个领域。
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