Parmar N S, Tariq M, Ageel A M, Al-Khamis K I
Int J Tissue React. 1986;8(1):67-70.
The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. The gastric anti-ulcer activity of domperidone was evident following a single dose as well as a 5-day pretreatment against all the three ulcerogenic drugs. However, the protection in the five-day pretreatment group was greater than in the single dose pretreatment group. It appears that the gastrokinetic properties of domperidone play a significant role in producing this anti-ulcer effect. The study substantiates the results of the clinical observations on the healing of gastric ulcers and provides a rationale for further clinical studies in that direction. The possible mechanisms of action of this agent are discussed.
已对外周多巴胺受体拮抗剂多潘立酮在阿司匹林、保泰松和利血平诱导的大鼠胃溃疡中的作用进行了研究。多潘立酮单次给药以及针对所有三种致溃疡药物进行5天预处理后，其抗胃溃疡活性均很明显。然而，5天预处理组的保护作用大于单次给药预处理组。多潘立酮的胃动力特性似乎在产生这种抗溃疡作用中起重要作用。该研究证实了胃溃疡愈合临床观察的结果，并为该方向的进一步临床研究提供了理论依据。讨论了该药物可能的作用机制。
