Tariq M, Parmar N S, Ageel A M
Toxicol Appl Pharmacol. 1985 Jun 30;79(2):268-73. doi: 10.1016/0041-008x(85)90348-5.
The effect of nicotine and caffeine pretreatment by feeding nicotine (2.5 mg %), caffeine (30 mg % base), and their combination (nicotine 2.5 mg % + caffeine 30 mg %) in drinking water ad libitum for 21 days was studied on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats. When given alone, neither nicotine nor caffeine produced any visibly discernible gastric lesions. Their concurrent administration too, did not produce any gastric mucosal injury. Pretreatment with nicotine, caffeine, and their combination resulted in significant augmentation of gastric ulcers produced by aspirin, phenylbutazone, and reserpine. However, caffeine administration produced a comparatively less profound augmentation of experimentally induced gastric lesions than that produced by nicotine pretreatment. The enhancement of gastric ulcers in the groups pretreated with the combination of nicotine and caffeine followed by one of the drugs was significantly greater than in the groups treated by either of them alone. The effect of nicotine on the mucus neck cell population of the gastric mucosa and on pancreatic bicarbonate secretion and the gastric secretory effect of caffeine may be responsible for the potentiation of the ulcerogenic effects of aspirin, phenylbutazone, and reserpine.
通过在大鼠饮用水中随意添加尼古丁（2.5毫克%）、咖啡因（30毫克%碱）及其组合（尼古丁2.5毫克% + 咖啡因30毫克%）进行21天的预处理，研究了尼古丁和咖啡因对阿司匹林、保泰松和利血平诱导的大鼠胃黏膜损伤的影响。单独给予时，尼古丁和咖啡因均未产生任何明显可见的胃部病变。它们同时给药也未造成任何胃黏膜损伤。尼古丁、咖啡因及其组合预处理导致阿司匹林、保泰松和利血平所致胃溃疡显著增加。然而，与尼古丁预处理相比，给予咖啡因对实验性诱导的胃部病变的增加作用相对较小。用尼古丁和咖啡因组合预处理后再给予其中一种药物的组中胃溃疡的增强程度明显大于单独使用其中任何一种药物治疗的组。尼古丁对胃黏膜黏液颈细胞群体、胰腺碳酸氢盐分泌的影响以及咖啡因的胃分泌作用可能是阿司匹林、保泰松和利血平致溃疡作用增强的原因。
