Tariq M, Parmar N S, Ageel A M
Alcohol Clin Exp Res. 1986 Mar-Apr;10(2):213-6. doi: 10.1111/j.1530-0277.1986.tb05074.x.
The effect of nicotine and alcohol pretreatment by feeding nicotine (2.5 mg/100 ml), alcohol (25%, v/v) and their combination (nicotine 2.5 mg/100 ml + alcohol 25%, v/v) in drinking water ad libitum for 21 days was studied on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats. When given alone, neither nicotine nor alcohol produced any visibly discernible gastric lesions. Their concurrent administration, however, produced minor injury to the gastric mucosa appearing as 5-7 circular ulcers of less than 1 mm in diameter. Pretreatment with nicotine, alcohol, and their combination resulted in the significant augmentation of gastric ulcers produced by aspirin, phenylbutazone, and reserpine. The augmentation of gastric lesions in the group pretreated with the combination of nicotine and alcohol was significantly greater than in the groups treated by either of them alone. The effect of nicotine on the mucus neck cell population of the gastric mucosa and pancreatic bicarbonate secretion, and the gastric mucosal damaging effect of chronic alcohol treatment may be responsible for the potentiation of ulcerogenic effects of aspirin, phenylbutazone, and reserpine.
通过在大鼠饮用水中随意添加尼古丁（2.5毫克/100毫升）、酒精（25%，体积/体积）及其组合（尼古丁2.5毫克/100毫升 + 酒精25%，体积/体积）进行21天的预处理，研究尼古丁和酒精对阿司匹林、保泰松和利血平诱导的大鼠胃黏膜损伤的影响。单独给予时，尼古丁和酒精均未产生任何明显可见的胃部病变。然而，它们同时给药时，对胃黏膜产生了轻微损伤，表现为5 - 7个直径小于1毫米的圆形溃疡。尼古丁、酒精及其组合预处理导致阿司匹林、保泰松和利血平引起的胃溃疡显著增加。尼古丁和酒精组合预处理组的胃损伤增加显著大于单独使用其中任何一种处理的组。尼古丁对胃黏膜黏液颈细胞数量和胰腺碳酸氢盐分泌的影响，以及慢性酒精处理对胃黏膜的损伤作用，可能是阿司匹林、保泰松和利血平致溃疡作用增强的原因。
