Wang Yuanwei, Ma Ke, Kang Miaomiao, Yan Dingyuan, Niu Niu, Yan Saisai, Sun Panpan, Zhang Luzhi, Sun Lijie, Wang Dong, Tan Hui, Tang Ben Zhong
Center for Child Care and Mental Health (CCCMH) Shenzhen Children's Hospital, Shenzhen 518026, P. R. China.
Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering Shenzhen University, Shenzhen 518060, P. R. China.
Chem Soc Rev. 2024 Dec 9;53(24):12014-12042. doi: 10.1039/d4cs00708e.
The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment in numerous cancer indications. Of particular interest is nanoscale photosensitizer-based phototherapy, which has been established as a prominent candidate for advanced tumor treatment by virtue of its high efficacy and safety. Despite considerable research progress on materials, methods and devices in nanoscale photosensitizing agent-based phototherapy, their mechanisms of action are not always clear, which impedes their practical application in cancer treatment. Hence, from a new perspective, this review elaborates the working mechanisms, involving impairment and moderation effects, of diverse phototherapies on cells, organelles, organs, and tissues. Furthermore, the most current available phototherapy modalities are categorized as photodynamic, photothermal, photo-immune, photo-gas, and radio therapies in this review. A comprehensive understanding of the inferiority and superiority of various phototherapies will facilitate the advent of a new era of cancer phototherapy.
在过去几十年中，光疗法作为一种实验性选择或经监管部门批准的治疗方法，在众多癌症适应症中取得了巨大进展。基于纳米级光敏剂的光疗法尤其令人关注，凭借其高效性和安全性，它已成为先进肿瘤治疗的突出候选方法。尽管基于纳米级光敏剂的光疗法在材料、方法和设备方面取得了相当大的研究进展，但其作用机制并不总是清晰的，这阻碍了它们在癌症治疗中的实际应用。因此，本综述从一个新的视角阐述了不同光疗法对细胞、细胞器、器官和组织的作用机制，包括损伤和调节作用。此外，本综述将当前可用的光疗法模式分为光动力疗法、光热疗法、光免疫疗法、光气疗法和放射疗法。全面了解各种光疗法的优缺点将有助于开启癌症光疗法的新时代。
