Department of Urology, Hai'an People's Hospital, Hai'an, Jiangsu, China.
Department of Urology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Medicine (Baltimore). 2024 Nov 1;103(44):e40353. doi: 10.1097/MD.0000000000040353.
This study aims to ascertain the associations between serum leptin levels and metabolic syndrome and semen parameters in patients with infertility. A total of 200 patients who were diagnosed as primary infertility in our hospital were enrolled in this study, and they were divided into MetS group and non-MetS group. About 30 healthy men were enrolled as the control group. The general information, blood lipids, reproductive hormones and semen parameters were collected. We used the Student t test, the Chi-square test, the Kruskal-Wallis test, and the spearman correlation analysis to analyze their relationships. BMI, glucose, TG, follicle-stimulating hormone (FSH), and leptin were significantly higher in MetS infertile patients (P < .001; P < .005; P < .001; P < .001; and P < .001, respectively). While T and high-density lipoprotein (HDL) were significantly lower in MetS infertile patients (P < .01, and P < .001, respectively). Leptin was correlated with sperm progressive motility (R = -0.312, P < .01), and normal morphology (R = -0.458, P < .001). Moreover, sperm concentration was correlated with FSH (R = -0.268, P < .001) and inhibin B (R = 0.401, P < .001), and normal morphology was correlated with HDL (R = 0.233, P < .001) and TG (R = -0.182, P < .01). In primary infertile patients, sperm normal morphology were found to be depressed and related to MetS. Leptin was increased in patients diagnosed with MetS and associated with semen parameters.
本研究旨在确定血清瘦素水平与代谢综合征（MetS）和不育症患者精液参数之间的关系。我们招募了 200 名在我院被诊断为原发性不育的患者，并将其分为 MetS 组和非 MetS 组。另外还招募了约 30 名健康男性作为对照组。收集了他们的一般信息、血脂、生殖激素和精液参数。我们使用学生 t 检验、卡方检验、Kruskal-Wallis 检验和 Spearman 相关分析来分析它们之间的关系。MetS 不育患者的 BMI、血糖、甘油三酯（TG）、卵泡刺激素（FSH）和瘦素明显更高（P<0.001；P<0.005；P<0.001；P<0.001；P<0.001）。而 T 和高密度脂蛋白（HDL）明显更低（P<0.01 和 P<0.001）。瘦素与精子前向运动（R=-0.312，P<0.01）和正常形态（R=-0.458，P<0.001）呈负相关。此外，精子浓度与 FSH（R=-0.268，P<0.001）和抑制素 B（R=0.401，P<0.001）呈负相关，正常形态与 HDL（R=0.233，P<0.001）和 TG（R=-0.182，P<0.01）呈正相关。在原发性不育患者中，发现精子正常形态下降，与 MetS 有关。MetS 患者瘦素增加，并与精液参数相关。
