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金黄色葡萄球菌再生原生质体中的质粒不稳定性是由异常细胞分裂引起的。

Plasmid instability in regenerating protoplasts of Staphylococcus aureus is caused by aberrant cell division.

作者信息

Gruss A, Novick R

出版信息

J Bacteriol. 1986 Mar;165(3):878-83. doi: 10.1128/jb.165.3.878-883.1986.

DOI:10.1128/jb.165.3.878-883.1986
PMID:3949716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC214510/
Abstract

Elimination of plasmids from regenerating S. aureus protoplasts occurred when the regeneration medium contained sucrose but not when it contained sodium succinate. This difference was caused by the occurrence of cell division prior to regeneration of the cell wall on sucrose but not on succinate. Coexisting compatible plasmids were cured independently; coexisting incompatible plasmids were cured jointly. These results support the hypothesis that plasmid pools exist as physically sequestered units in protoplasts and that curing is a consequence of the segregation of such units during abnormal division of wall-less organisms.

摘要

当再生培养基含有蔗糖时，金黄色葡萄球菌原生质体再生过程中质粒会消除，而当含有琥珀酸钠时则不会。这种差异是由于在蔗糖上细胞壁再生之前发生了细胞分裂，而在琥珀酸钠上则没有。共存的相容性质粒会独立消除；共存的不相容性质粒会共同消除。这些结果支持了以下假设：质粒库在原生质体中以物理隔离的单位存在，并且消除是无壁生物体异常分裂过程中这些单位分离的结果。

相似文献

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Plasmid instability in regenerating protoplasts of Staphylococcus aureus is caused by aberrant cell division.金黄色葡萄球菌再生原生质体中的质粒不稳定性是由异常细胞分裂引起的。
J Bacteriol. 1986 Mar;165(3):878-83. doi: 10.1128/jb.165.3.878-883.1986.
2
Plasmid transfer and genetic recombination by protoplast fusion in staphylococci.葡萄球菌中通过原生质体融合进行的质粒转移和基因重组
J Bacteriol. 1981 Jan;145(1):74-81. doi: 10.1128/jb.145.1.74-81.1981.
3
[Isolation of Staphylococcus aureus protoplasts using lysoamidase].[使用溶菌酰胺酶分离金黄色葡萄球菌原生质体]
Prikl Biokhim Mikrobiol. 1990 May-Jun;26(3):413-21.
4
DOMINANCE OF THE INDUCIBLE STATE IN STRAINS OF STAPHYLOCOCCUS AUREUS CONTAINING TWO DISTINCT PENICILLINASE PLASMIDS.含两种不同青霉素酶质粒的金黄色葡萄球菌菌株中可诱导状态的优势
J Bacteriol. 1965 Aug;90(2):370-4. doi: 10.1128/jb.90.2.370-374.1965.
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Involvement of the cell envelope in plasmid maintenance: plasmid curing during the regeneration of protoplasts.细胞包膜在质粒维持中的作用：原生质体再生过程中的质粒消除
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Isolation, structural and functional characterization of Staphylococcus aureus protoplasts obtained using lysoamidase.使用溶菌酰胺酶获得的金黄色葡萄球菌原生质体的分离、结构和功能表征。
Arch Microbiol. 1991;155(6):549-53. doi: 10.1007/BF00245348.
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Growth and division of protoplasts of Bacillus megaterium and inhibition of division by penicillin.巨大芽孢杆菌原生质体的生长与分裂以及青霉素对其分裂的抑制作用。
J Bacteriol. 1967 Oct;94(4):884-8. doi: 10.1128/jb.94.4.884-888.1967.
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Cell fusion between L-forms and protoplasts of Staphylococcus aureus.金黄色葡萄球菌L型与原生质体之间的细胞融合。
Biken J. 1985 Dec;28(3-4):59-70.
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Effect of the composition of reversion medium on change of Staphylococcus aureus lysostaphin protoplasts to coccal forms and L-forms.回复培养基组成对金黄色葡萄球菌溶葡萄球菌素原生质体转变为球菌形态和L型的影响。
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Properties of a temperature-sensitive mutant of Staphylococcus aureus defective in DNA replication and cell division and replication of plasmids in the mutant.金黄色葡萄球菌温度敏感突变体的特性，该突变体在DNA复制、细胞分裂以及质粒在突变体中的复制方面存在缺陷。
J Gen Microbiol. 1978 Jun;106(2):361-8. doi: 10.1099/00221287-106-2-361.

引用本文的文献

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Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus.金黄色葡萄球菌中晚期多聚核糖醇磷酸壁磷壁酸生物合成
J Bacteriol. 2008 Apr;190(8):3046-56. doi: 10.1128/JB.01880-07. Epub 2008 Feb 15.

本文引用的文献

1
Cell-wall synthesis by Staphylococcus aureus in the presence of chloramphenicol.金黄色葡萄球菌在氯霉素存在下的细胞壁合成
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Binding between the par region of plasmids R1 and pSC101 and the outer membrane fraction of the host bacteria.
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Replication of a low-copy-number plasmid by a plasmid DNA-membrane complex extracted from minicells of Escherichia coli.从大肠杆菌微小细胞中提取的质粒DNA-膜复合物对低拷贝数质粒的复制。
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Complementation of a plasmid replication defect by autonomous incompatible plasmids in Staphylococcus aureus.金黄色葡萄球菌中自主不兼容质粒对质粒复制缺陷的互补作用。
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Involvement of the cell envelope in plasmid maintenance: plasmid curing during the regeneration of protoplasts.细胞包膜在质粒维持中的作用：原生质体再生过程中的质粒消除
Plasmid. 1980 May;3(3):348-58. doi: 10.1016/0147-619x(80)90048-7.
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Partitioning of plasmid R1 in Escherichia coli. I. Kinetics of loss of plasmid derivatives deleted of the par region.质粒R1在大肠杆菌中的分配。I. 缺失par区域的质粒衍生物的丢失动力学。
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Regions on the F plasmid which affect plasmid maintenance and the ability to segregate into Escherichia coli minicells.F质粒上影响质粒维持及向大肠杆菌微小细胞中分离能力的区域。
Plasmid. 1982 Jul;8(1):36-44. doi: 10.1016/0147-619x(82)90039-7.
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How crowded is the cytoplasm?细胞质的拥挤程度如何？
Cell. 1982 Sep;30(2):345-7. doi: 10.1016/0092-8674(82)90231-8.
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Control of pT181 replication I. The pT181 copy control function acts by inhibiting the synthesis of a replication protein.pT181复制的控制 一、pT181拷贝控制功能通过抑制一种复制蛋白的合成来发挥作用。
EMBO J. 1984 Oct;3(10):2399-405. doi: 10.1002/j.1460-2075.1984.tb02146.x.
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Multimerization of high copy number plasmids causes instability: CoIE1 encodes a determinant essential for plasmid monomerization and stability.高拷贝数质粒的多聚化会导致不稳定性：ColE1编码一个对质粒单体化和稳定性至关重要的决定因素。
Cell. 1984 Apr;36(4):1097-103. doi: 10.1016/0092-8674(84)90060-6.