May G L, Wright L C, Holmes K T, Williams P G, Smith I C, Wright P E, Fox R M, Mountford C E
J Biol Chem. 1986 Mar 5;261(7):3048-53.
Some biological characteristics of cancer cells and solid tumors are identifiable by the high resolution NMR relaxation behavior of their nonaqueous components. Chemical analysis and two-dimensional scalar correlated (COSY) NMR spectroscopy show these resonances arise from neutral lipid in the plasma membrane. Triglyceride is shown to be the main plasma membrane component giving rise to the NMR spectrum, while soluble nonmembrane components account for 90% of the remaining resonances in the spectrum of intact cells. The presence of triglyceride has been detected by chemical analysis in highly purified plasma membranes from two different cell lines. The COSY spectra of cancer cells are comparable with that obtained for the triglyceride-rich very low density human lipoprotein.
癌细胞和实体瘤的一些生物学特性可通过其非水成分的高分辨率核磁共振弛豫行为来识别。化学分析和二维标量相关（COSY）核磁共振光谱表明，这些共振源于质膜中的中性脂质。甘油三酯被证明是产生核磁共振谱的主要质膜成分，而可溶性非膜成分占完整细胞谱中其余共振的90%。通过化学分析已在来自两种不同细胞系的高度纯化质膜中检测到甘油三酯的存在。癌细胞的COSY谱与富含甘油三酯的极低密度人脂蛋白的谱相当。
