Corbeau Anouk, van Gastel Pien, Wielopolski Piotr A, de Jong Nick, Creutzberg Carien L, van der Heide Uulke A, de Boer Stephanie M, Astreinidou Eleftheria
Department of Radiation Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands.
Department of Radiology and Nuclear Medicine, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Phys Imaging Radiat Oncol. 2024 Sep 27;32:100651. doi: 10.1016/j.phro.2024.100651. eCollection 2024 Oct.
Bone marrow (BM) damage due to chemoradiotherapy can increase BM fat in cervical cancer patients. Water-fat magnetic resonance (MR) scans were performed on a phantom and a healthy female volunteer to validate proton density fat fraction accuracy, reproducibility, and repeatability across different vendors, field strengths, and protocols. Phantom measurements showed a high accuracy, high repeatability, and excellent reproducibility. Volunteer measurements had an excellent intra- and interreader reliability, good repeatability, and moderate to good reproducibility. Water-fat MRI show potential for quantification of longitudinal vertebral BM fat changes. Further studies are needed to validate and extend these findings for broader clinical applicability.
放化疗导致的骨髓（BM）损伤会增加宫颈癌患者的骨髓脂肪。对一个体模和一名健康女性志愿者进行了水脂磁共振（MR）扫描，以验证质子密度脂肪分数在不同供应商、场强和协议下的准确性、可重复性和重复性。体模测量显示出高精度、高重复性和出色的可重复性。志愿者测量在阅片者内和阅片者间具有出色的可靠性、良好的重复性以及中等至良好的可重复性。水脂MRI显示出对纵向椎体骨髓脂肪变化进行量化的潜力。需要进一步研究来验证和扩展这些发现，以实现更广泛的临床应用。
