Kawamoto Terufumi, Shikama Naoto, Nakamura Naoki, Mizowaki Takashi
Department of Radiation Oncology, Juntendo University, Graduate School of Medicine, Tokyo, Japan.
Department of Radiation Oncology, St. Marianna University School of Medicine Hospital, Kyoto, Kanagawa, Japan.
Jpn J Clin Oncol. 2025 Feb 4;55(2):95-99. doi: 10.1093/jjco/hyae158.
The treatment options for differentiated thyroid cancer (DTC) are surgery, thyroid stimulating hormone suppression, radioactive iodine, and multitargeted tyrosine kinase inhibitors. The role of external-beam radiotherapy (EBRT) for DTC is controversial because of the lack of randomized controlled trials, but prospective single-arm studies and propensity score matching analyses have shown its efficacy and safety. This review discusses the role of EBRT after resection of gross disease, when there is a high risk of locoregional failure, as well as its role for locoregionally gross recurrent and unresectable disease. As in other tumor sites, EBRT has an important role in the palliative management and local control of patients with metastatic DTC, especially with bone and brain metastases.
分化型甲状腺癌（DTC）的治疗选择包括手术、促甲状腺激素抑制、放射性碘和多靶点酪氨酸激酶抑制剂。由于缺乏随机对照试验，外照射放疗（EBRT）在DTC中的作用存在争议，但前瞻性单臂研究和倾向评分匹配分析已显示出其有效性和安全性。本综述讨论了在大体疾病切除后，当存在局部区域复发高风险时EBRT的作用，以及其在局部区域大体复发和不可切除疾病中的作用。与其他肿瘤部位一样，EBRT在转移性DTC患者的姑息治疗和局部控制中具有重要作用，尤其是对于骨转移和脑转移患者。
