Department of Dermatology in Zagazig University, Zagazig, Egypt.
Department of Pathology in Zagazig University, Zagazig, Egypt.
Arch Dermatol Res. 2024 Nov 5;316(10):742. doi: 10.1007/s00403-024-03452-9.
Oral Lichen Planus (OLP) is a chronic inflammatory mucocutaneous disorder of the oral mucosa. Th9 cells secrete IL9, which induces elevated levels of MMP9, exacerbating OLP disease severity. IL9 also increases Th17 levels in OLP lesions. This study aimed to detect IL9 tissue expression in patients with OLP compared to normal controls and to correlate its expression with disease severity and response to intralesional steroid therapy. This study involved 18 patients with OLP and 18 healthy, age- and sex-matched volunteers. The REU scoring system was used to monitor OLP lesions before and after treatment with 20 mg/mL intralesional triamcinolone acetonide every 2 weeks for four sessions. Biopsies for H&E and IL-9 expression were taken from patients and controls, with repeat biopsies after the fourth session for patients. A highly statistically significant increase in IL9 expression was observed in the patient group compared with the control group. A highly statistically significant decrease in both the REU score and post-treatment IL-9 expression was detected in the patient group. We can conclude that IL9 is a tissue marker of OLP activity. Future studies on therapies targeting IL-9 in OLP are needed.
口腔扁平苔藓（OLP）是一种口腔黏膜的慢性炎症性黏膜疾病。Th9 细胞分泌的 IL9 诱导 MMP9 水平升高，从而加重 OLP 的疾病严重程度。IL9 还会增加 OLP 病变中的 Th17 水平。本研究旨在检测 OLP 患者与正常对照组之间的组织中 IL9 的表达，并将其表达与疾病严重程度和对局部皮质类固醇治疗的反应相关联。本研究纳入了 18 名 OLP 患者和 18 名年龄和性别匹配的健康志愿者。使用 REU 评分系统监测 OLP 病变，在每 2 周进行 4 次 20mg/mL 局部曲安奈德治疗前后进行。对患者和对照组进行 H&E 和 IL-9 表达的活检，并对患者进行第 4 次治疗后的重复活检。与对照组相比，患者组的 IL9 表达显著增加。在患者组中，REU 评分和治疗后 IL-9 表达均显著降低。我们可以得出结论，IL9 是 OLP 活动的组织标志物。需要进一步研究针对 OLP 中 IL-9 的治疗方法。
