Breast Cancer Chemoprevention from Nano Roscoe.

BACKGROUND

After cardiovascular disease, cancer is one of the leading causes of death due to uncontrolled cell growth. Breast cancer is among the most prevalent types of cancer. Roscoe. rich in phenolic compounds, which can stimulate and function as endogenous antioxidants.

PURPOSE

Investigation of the in vivo chemopreventive has the potential of nano Roscoe (Zo-NPs) in breast cancer.

STUDY DESIGN

Using female Balb/c induced with benzo[α]pyrene, the chemopreventive action of Roscoe. nanoencapsulated using κ-carrageenan was assessed.

RESULTS

Roscoe Extract. contains 58 compounds, with the main component being [6]-gingerol with [6]-gingerol content being 697.65 ± 8.52 mg/g extract. Nanoencapsulation of Roscoe. has been successfully prepared with a particle size of 483.30 ± 11.23 nm. Zo-NPs are generally resistant to pH, temperature, and salt content variations. Compared to group C, which underwent ductular dilatation, the administration of Zo-NPs (group T) to female Balb/c, induced by benzo[α]pyrene, revealed no histological alterations in breast tissue. Moreover, administering Zo-NPs can raise blood serum levels of CAT, GSH, and SOD. In addition, it showed a greater ability to lower TNF-α levels than the T group, which received Roscoe extract. (Zo).