Zhang Penghong, Zhao Jiangzhe, Zhang Wei, Guo Yongfeng, Zhang Kewei
Zhejiang Provincial Key Laboratory of Biotechnology on Specialty Economic Plants, College of Life Sciences, Zhejiang Normal University, Jinhua, Zhejiang, China.
Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong, China.
Front Plant Sci. 2024 Oct 22;15:1474111. doi: 10.3389/fpls.2024.1474111. eCollection 2024.
Peptide hormones regulate plant development, growth, and stress responses. Sulfated peptides represent a class of proteins that undergo posttranslational modification by tyrosylprotein sulfotransferase (TPST), followed by specific enzymatic cleavage to generate mature peptides. This process contributes to the formation of various bioactive peptides, including PSKs (PHYTOSULFOKINEs), PSYs (PLANT PEPTIDE CONTAINING SULFATED TYROSINE), CIFs (CASPARIAN STRIP INTEGRITY FACTOR), and RGFs (ROOT MERISTEM GROWTH FACTOR). In the past three decades, significant progress has been made in understanding the molecular mechanisms of sulfated peptides that regulate plant development, growth, and stress responses. In this review, we explore the sequence properties of precursors, posttranslational modifications, peptide receptors, and signal transduction pathways of the sulfated peptides, analyzing their functions in plants. The cross-talk between PSK/RGF peptides and other phytohormones, such as brassinosteroids, auxin, salicylic acid, abscisic acid, gibberellins, ethylene, and jasmonic acid, is also described. The significance of sulfated peptides in crops and their potential application for enhancing crop productivity are discussed, along with future research directions in the study of sulfated peptides.
肽激素调节植物的发育、生长和应激反应。硫酸化肽是一类经过酪氨酰蛋白硫酸转移酶（TPST）进行翻译后修饰，随后经特定酶切产生成熟肽的蛋白质。这一过程有助于形成各种生物活性肽，包括植物硫肽（PHYTOSULFOKINEs，PSKs）、含硫酸化酪氨酸的植物肽（PLANT PEPTIDE CONTAINING SULFATED TYROSINE，PSYs）、凯氏带完整性因子（CASPARIAN STRIP INTEGRITY FACTOR，CIFs）和根分生组织生长因子（ROOT MERISTEM GROWTH FACTOR，RGFs）。在过去三十年里，在理解调节植物发育、生长和应激反应的硫酸化肽的分子机制方面取得了重大进展。在本综述中，我们探讨了硫酸化肽前体的序列特性、翻译后修饰、肽受体和信号转导途径，分析了它们在植物中的功能。还描述了PSK/RGF肽与其他植物激素（如油菜素内酯、生长素、水杨酸、脱落酸、赤霉素、乙烯和茉莉酸）之间的相互作用。讨论了硫酸化肽在作物中的意义及其在提高作物生产力方面的潜在应用，以及硫酸化肽研究的未来方向。
