Eisenberg Matthew T, Hustedt Joshua W
Orthopedic Surgery, University of Arizona College of Medicine - Phoenix, Phoenix, USA.
Hand Surgery, University of Arizona College of Medicine - Phoenix, Phoenix, USA.
Cureus. 2024 Oct 27;16(10):e72480. doi: 10.7759/cureus.72480. eCollection 2024 Oct.
The use of alginate, a derivative of seaweed, has been proposed for multiple orthopedic indications. We aimed to review the current use of alginate in orthopedics and to focus on the future applications of alginate for peripheral nerve repair. A comprehensive literature search was performed to identify biomechanical, laboratory, animal, and human studies where alginate has been utilized for orthopedic or nerve repair indications. A systematic review of orthopedic indications was conducted for safety and efficacy, and a specific focus was placed on alginate for use in peripheral nerve repair and reconstruction. Thirty-two studies were identified. Alginate has a strong history and safety profile for usage in orthopedic surgery. Its primary usage has been for the repair of articular cartilage, although it has also been used for disc regeneration of the lumbar spine and for cushioning joints in osteoarthritis. The primary indication in peripheral nerve repair is to create an environment that encourages Schwann cell migration and repair in nerve injuries while blocking fibrotic scar tissue formation by inhibiting the activity of fibroblasts. Alginate hydrogel may serve as a potential conduit for nerve regeneration in nerve injuries with small to medium-sized gaps.
海藻酸盐是一种海藻衍生物，已被提议用于多种骨科适应症。我们旨在回顾海藻酸盐在骨科中的当前应用，并重点关注海藻酸盐在周围神经修复中的未来应用。进行了全面的文献检索，以确定海藻酸盐已用于骨科或神经修复适应症的生物力学、实验室、动物和人体研究。对骨科适应症进行了安全性和有效性的系统评价，并特别关注海藻酸盐在周围神经修复和重建中的应用。共确定了32项研究。海藻酸盐在骨科手术中的使用有着悠久的历史且安全性良好。其主要用途是修复关节软骨，不过它也被用于腰椎间盘再生以及骨关节炎中关节的缓冲。周围神经修复的主要适应症是创造一个促进雪旺细胞迁移和神经损伤修复的环境，同时通过抑制成纤维细胞的活性来阻止纤维化瘢痕组织的形成。海藻酸盐水凝胶可作为一种潜在的导管，用于修复中小间隙的神经损伤中的神经再生。
