Buck G E, Gourley W K, Lee W K, Subramanyam K, Latimer J M, DiNuzzo A R
J Infect Dis. 1986 Apr;153(4):664-9. doi: 10.1093/infdis/153.4.664.
Biopsy specimens from the gastric antral mucosa of 50 patients with upper gastrointestinal complaints were studied by light and electron microscopy and culture. Of 46 assessable specimens, seven were histologically normal, and 39 showed evidence of gastritis. Twenty-seven of the specimens with evidence of gastritis (69%) contained spiral bacteria, whereas only one of the normal specimens (14%) contained these bacteria (P = .02). Of 17 patients found to have gastric ulcers, 10 (59% [P greater than .10] ) also had spiral bacteria. The bacteria could be seen scattered over the surface of the epithelial cells and just under the layer of mucus but were rarely found inside the epithelial cells. Curved or spiral gramnegative bacilli were isolated from 10 of the specimens on chocolate agar incubated at 37 C under microaerophilic conditions. The bacteria resembled the organism recently named Campylobacter pyloridis by other investigators.
对50例有上消化道症状患者的胃窦黏膜活检标本进行了光镜、电镜检查及培养。在46份可评估标本中，7份组织学正常，39份有胃炎证据。27份有胃炎证据的标本（69%）含有螺旋菌，而正常标本中只有1份（14%）含有这些细菌（P = 0.02）。在17例发现有胃溃疡的患者中，10例（59%[P大于0.10]）也有螺旋菌。细菌可见于上皮细胞表面及黏液层下方，但很少见于上皮细胞内。在微需氧条件下于37℃培养的巧克力琼脂上，从10份标本中分离出弯曲或螺旋状革兰阴性杆菌。这些细菌类似于其他研究者最近命名的幽门弯曲菌。
