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核心技术专利：CN118964589B侵权必究
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铁硫簇依赖的酶和钼依赖的还原酶在人类肠道微生物的厌氧代谢中。

Iron-sulfur cluster-dependent enzymes and molybdenum-dependent reductases in the anaerobic metabolism of human gut microbes.

机构信息

De partment of Chemistry, University of Washington, Seattle, United States.

出版信息

Metallomics. 2024 Nov 7;16(11). doi: 10.1093/mtomcs/mfae049.

DOI:10.1093/mtomcs/mfae049
PMID:39504489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11574389/
Abstract

Metalloenzymes play central roles in the anaerobic metabolism of human gut microbes. They facilitate redox and radical-based chemistry that enables microbial degradation and modification of various endogenous, dietary, and xenobiotic nutrients in the anoxic gut environment. In this review, we highlight major families of iron-sulfur (Fe-S) cluster-dependent enzymes and molybdenum cofactor-containing enzymes used by human gut microbes. We describe the metabolic functions of 2-hydroxyacyl-CoA dehydratases, glycyl radical enzyme activating enzymes, Fe-S cluster-dependent flavoenzymes, U32 oxidases, and molybdenum-dependent reductases and catechol dehydroxylases in the human gut microbiota. We demonstrate the widespread distribution and prevalence of these metalloenzyme families across 5000 human gut microbial genomes. Lastly, we discuss opportunities for metalloenzyme discovery in the human gut microbiota to reveal new chemistry and biology in this important community.

摘要

金属酶在人类肠道微生物的厌氧代谢中起着核心作用。它们促进了氧化还原和基于自由基的化学，使微生物能够在缺氧的肠道环境中降解和修饰各种内源性、饮食和外源性营养物质。在这篇综述中，我们强调了人类肠道微生物使用的主要铁硫 (Fe-S) 簇依赖性酶和钼辅因子依赖性酶家族。我们描述了 2-羟酰基辅酶 A 脱水酶、甘氨酰基自由基酶激活酶、Fe-S 簇依赖性黄素酶、U32 氧化酶以及钼依赖性还原酶和儿茶酚脱羟基酶在人类肠道微生物群中的代谢功能。我们证明了这些金属酶家族在 5000 个人类肠道微生物基因组中的广泛分布和普遍性。最后，我们讨论了在人类肠道微生物群中发现金属酶的机会，以揭示这个重要群落中的新化学和生物学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/f4014761086b/mfae049fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/c254e61e095b/mfae049fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/0d7cd5d36501/mfae049fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/81d808fc7a1b/mfae049fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/2e7bc3bf4543/mfae049fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/040cc462fad2/mfae049fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/d87b91b82772/mfae049fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/56269a61cc70/mfae049fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/f4014761086b/mfae049fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/c254e61e095b/mfae049fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/0d7cd5d36501/mfae049fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/81d808fc7a1b/mfae049fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/2e7bc3bf4543/mfae049fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/040cc462fad2/mfae049fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/d87b91b82772/mfae049fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/56269a61cc70/mfae049fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ab/11574389/f4014761086b/mfae049fig7.jpg

相似文献

[1]
Iron-sulfur cluster-dependent enzymes and molybdenum-dependent reductases in the anaerobic metabolism of human gut microbes.

Metallomics. 2024-11-7

[2]
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols.

Elife. 2020-2-18

[3]
Molybdenum-cofactor-containing enzymes: structure and mechanism.

Annu Rev Biochem. 1997

[4]
The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria.

Biochim Biophys Acta. 2015-6

[5]
Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity.

Gut Microbes. 2018-6-4

[6]
Redox centers of 4-hydroxybenzoyl-CoA reductase, a member of the xanthine oxidase family of molybdenum-containing enzymes.

J Biol Chem. 2001-12-21

[7]
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.

Proc Natl Acad Sci U S A. 2020-6-22

[8]
Glycyl Radical Enzymes and Sulfonate Metabolism in the Microbiome.

Annu Rev Biochem. 2021-6-20

[9]
Elucidation of an anaerobic pathway for metabolism of l-carnitine-derived γ-butyrobetaine to trimethylamine in human gut bacteria.

Proc Natl Acad Sci U S A. 2021-8-10

[10]
Functional mononuclear molybdenum enzymes: challenges and triumphs in molecular cloning, expression, and isolation.

J Biol Inorg Chem. 2020-6

引用本文的文献

[1]
NRVS of FeS cluster proteins & models - A bestiary of nifty normal modes.

J Inorg Biochem. 2025-9

[2]
Commensal resilience: ancient ecological lessons for the modern microbiota.

Infect Immun. 2025-6-10

本文引用的文献

[1]
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.

Cell. 2024-6-6

[2]
Accurate structure prediction of biomolecular interactions with AlphaFold 3.

Nature. 2024-6

[3]
An organic O donor for biological hydroxylation reactions.

Proc Natl Acad Sci U S A. 2024-3-26

[4]
Discovery of metal-binding proteins by thermal proteome profiling.

Nat Chem Biol. 2024-6

[5]
Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.

Nat Microbiol. 2024-1

[6]
BilR is a gut microbial enzyme that reduces bilirubin to urobilinogen.

Nat Microbiol. 2024-1

[7]
EFI-EST, EFI-GNT, and EFI-CGFP: Enzyme Function Initiative (EFI) Web Resource for Genomic Enzymology Tools.

J Mol Biol. 2023-7-15

[8]
Role of the ubiquinone-synthesizing UbiUVT pathway in adaptation to changing respiratory conditions.

mBio. 2023-8-31

[9]
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.

Microbiome. 2023-5-8

[10]
Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily.

Annu Rev Biochem. 2023-6-20

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