Tsui Yee, Wu Xueqi, Zhang Xi, Peng Ye, Mok Chris Ka Pun, Chan Francis K L, Ng Siew C, Tun Hein Min
HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Trends Microbiol. 2025 Mar;33(3):302-320. doi: 10.1016/j.tim.2024.10.001. Epub 2024 Nov 5.
Viral infections can cause cellular pathway derangements, cell death, and immunopathological responses, leading to host inflammation. Short-chain fatty acids (SCFAs), produced by the microbiota, have emerged as a potential therapeutic for viral infections due to their ability to modulate these processes. However, SCFAs have been reported to have both beneficial and detrimental effects, necessitating a comprehensive understanding of the underlying mechanisms. This review highlights the complex mechanisms underlying SCFAs' effects on viral infection outcomes. We also emphasize the importance of considering how SCFAs' activities may differ under diverse contexts, including but not limited to target cells with different metabolic wiring, different viral causes of infection, the target organism/cell's nutrient availability and/or energy balance, and hosts with varying microbiome compositions.
病毒感染可导致细胞信号通路紊乱、细胞死亡和免疫病理反应，进而引发宿主炎症。微生物群产生的短链脂肪酸（SCFAs），因其具有调节上述过程的能力，已成为病毒感染的一种潜在治疗手段。然而，据报道，SCFAs具有利弊双重影响，因此有必要全面了解其潜在机制。本综述着重介绍了SCFAs对病毒感染结果产生影响的复杂机制。我们还强调了考虑SCFAs在不同情况下（包括但不限于具有不同代谢途径的靶细胞、不同的病毒感染病因、靶生物/细胞的营养可利用性和/或能量平衡，以及具有不同微生物群组成的宿主）其活性可能存在差异的重要性。
