小鼠、大鼠、兔和人血清及脑组织中胍基化合物的比较研究。
Comparative study of guanidino compounds in serum and brain of mouse, rat, rabbit, and man.
作者信息
Marescau B, De Deyn P, Wiechert P, Van Gorp L, Lowenthal A
出版信息
J Neurochem. 1986 Mar;46(3):717-20. doi: 10.1111/j.1471-4159.1986.tb13030.x.
The levels of 12 guanidino compounds were determined in the serum and brain of mouse, rat, rabbit, and man using cation-exchange column chromatography with the fluorescence ninhydrin detection method. A comparative study of these compounds was made in the four groups studied, for serum and brain. In rabbit and man the different guanidino compounds were also determined in various brain regions. This study provides basic analytical data that could facilitate the interpretation of further biochemical and neurochemical studies dealing with guanidino compounds that are identified as being toxins in hyperargininemia and uremia.
采用阳离子交换柱色谱法结合茚三酮荧光检测法，测定了小鼠、大鼠、兔和人的血清及脑中12种胍基化合物的含量。对这四组研究对象的血清和脑进行了这些化合物的比较研究。在兔和人的不同脑区也测定了不同的胍基化合物。本研究提供了基础分析数据，有助于解释进一步关于胍基化合物的生化和神经化学研究，这些胍基化合物在高精氨酸血症和尿毒症中被鉴定为毒素。
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