Pujos Muriel, Chamayou-Robert Cécile, Parat Marine, Bonnet Magali, Couret Sandra, Robiolo Alessia, Doucet Olivier
COTY Research and Development, Monaco, Monaco.
J Cosmet Dermatol. 2025 Jan;24(1):e16634. doi: 10.1111/jocd.16634. Epub 2024 Nov 6.
Skin is continuously exposed to environmental external and internal factors, including psychological stress (PS). PS has been reported to trigger different dermatoses such as psoriasis, atopic dermatitis, vitiligo, alopecia areata, and acne through the release of cortisol and epinephrine.
To clinically explore PS-induced measurable skin aging signs in subjects with moderate versus mild chronic PS, and to investigate the effect of chronic PS on DNA damage at cellular level.
In vitro stress tests with cortisol and epinephrine, and with cortisol only on extracellular matrix (ECM) synthesis, as well as on normal human skin fibroblast and keratinocyte functioning, including skin barrier and wound healing were performed.
Moderately stressed subjects in the context of the clinical study had a significantly decreased antioxidant potential and impacted skin barrier integrity, as well as significantly increased signs of microrelief alterations (skin texture and fine lines) reaching an increased severity of about 32.9%. At a cellular level, DNA integrity, ECM synthesis, wound healing, and skin barrier parameters were impacted by increased stress hormone levels.
The clinical exploratory studies presented herewith, as well as the study of cell functioning under stress, have provided evidence that chronic PS significantly affects skin homeostasis and triggers skin aging.
皮肤持续暴露于环境中的外部和内部因素，包括心理压力（PS）。据报道，PS通过释放皮质醇和肾上腺素引发不同的皮肤病，如银屑病、特应性皮炎、白癜风、斑秃和痤疮。
临床探索中度与轻度慢性PS患者中PS诱导的可测量皮肤衰老迹象，并研究慢性PS对细胞水平DNA损伤的影响。
进行了皮质醇和肾上腺素以及仅皮质醇对细胞外基质（ECM）合成、正常人皮肤成纤维细胞和角质形成细胞功能（包括皮肤屏障和伤口愈合）的体外应激试验。
在临床研究中，中度应激受试者的抗氧化能力显著降低，皮肤屏障完整性受到影响，微起伏改变（皮肤质地和细纹）迹象显著增加，严重程度增加约32.9%。在细胞水平上，DNA完整性、ECM合成、伤口愈合和皮肤屏障参数受到应激激素水平升高的影响。
本文提出的临床探索性研究以及应激条件下细胞功能的研究提供了证据，证明慢性PS会显著影响皮肤稳态并引发皮肤衰老。
