Claassen-Weitz Shantelle, du Toit Elloise, Gardner-Lubbe Sugnet, Kullin Brian, Bellairs Gregory, Hilton Caroline, Chicken Anika, Welp Kirsten, Livingstone Hannah, Brink Adrian
Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Department of Statistics and Actuarial Sciences, Faculty of Economic and Management Sciences, Stellenbosch University, Stellenbosch, South Africa.
S Afr J Infect Dis. 2024 Oct 31;39(1):645. doi: 10.4102/sajid.v39i1.645. eCollection 2024.
The complexity of contexts and varied purposes for which biome donation are requested are unknown in South Africa.
The aim of this study was to provide strategic data towards actualisation of whether a stool donor bank may be established as a collaborative between Western Cape Blood Services (WCBS) and the University of Cape Town (UCT).
We designed a cross-sectional, questionnaire-based survey to determine willingness of WCBS blood donors to donate stool specimens for microbiome biobanking. The study was conducted between 01 June 2022 and 01 July 2022 at three WCBS donation centres in Cape Town, South Africa. Anonymous blood donors who met the inclusion criteria were enrolled. Anonymised demographic and interview data were analysed statistically.
Analysis of responses from 209/231 blood donors demonstrated in a logistic regression model that compensation ( < 0.001) and 'societal benefit outweighs inconvenience' beliefs ( = 7.751e-05) were covariates significantly associated with willingness to donate stool. Age was borderline significant at a 5% level ( = 0.0556). Most willing stool donors indicated that donating stool samples would not affect blood donations (140/157, 90%). Factors decreasing willingness to donate were stool collection being unpleasant or embarrassing.
The survey provides strategic data for the establishment of a stool bank and provided an understanding of the underlying determinants regarding becoming potential donors.
This is the first report on the perspectives of potential participants in donating samples towards a stool microbiome biobank in South Africa, a necessity for faecal microbiota transplantation (FMT).
在南非，生物群落捐赠所涉及的背景复杂性以及请求捐赠的各种不同目的尚不清楚。
本研究的目的是提供战略数据，以实现西开普血液服务中心（WCBS）和开普敦大学（UCT）之间是否可以合作建立粪便捐赠库。
我们设计了一项基于问卷调查的横断面研究，以确定WCBS献血者捐赠粪便样本用于微生物群落生物样本库的意愿。该研究于2022年6月1日至2022年7月1日在南非开普敦的三个WCBS献血中心进行。纳入符合纳入标准的匿名献血者。对匿名的人口统计学和访谈数据进行统计分析。
对209/231名献血者的回复进行分析，在逻辑回归模型中表明，补偿（<0.001）和“社会效益大于不便”的信念（=7.751e-05）是与粪便捐赠意愿显著相关的协变量。年龄在5%的水平上接近显著（=0.0556）。大多数愿意捐赠粪便的人表示，捐赠粪便样本不会影响献血（140/157，90%）。降低捐赠意愿的因素是粪便采集不愉快或尴尬。
该调查为建立粪便库提供了战略数据，并有助于了解成为潜在捐赠者的潜在决定因素。
这是关于南非粪便微生物群落生物样本库样本捐赠潜在参与者观点的第一份报告，这是粪便微生物群移植（FMT）的必要条件。
