Zhang Hongjie, Jiang Xuan, Bai Lei, Chen Jiahui, Luo Wei, Ma Jianxiong, Ma Xinlong
Dehong People's Hospital, Kunming Medical University Affiliated Dehong Hospital, Mangshi, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Nutr. 2024 Oct 23;11:1409578. doi: 10.3389/fnut.2024.1409578. eCollection 2024.
The role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between vitamin C intake and OA.
Clinical information on participants during NHANES 2003-2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling. In MR analyses, three methods were used to explore the causality of vitamin C intake with OA. Sensitivity analysis to verify the stability of the MR study.
The cross-sectional study included a total of 31,527 participants, categorizing them into low (<30.2 mg), medium (30.2-93.0 mg) and high (>93.0 mg) level groups based on their vitamin C intake levels. Logistic regression models showed that vitamin C intake was not associated with OA risk ( > 0.05). Inverse-variance weighted (IVW) method of MR study showed no causality between vitamin C intake and OA (OR = 0.993, 95% CI: 0.901 ~ 1.095, = 0.882). Sensitivity analysis indicated that the MR study was reliable.
Our cross-sectional and MR studies showed that vitamin C intake was not associated with OA risk. More researches are needed in the future to investigate the link between vitamin C and OA.
维生素C在骨关节炎（OA）中的作用仍是一个有争议的话题。我们的目的是结合美国国家健康与营养检查调查（NHANES）和磁共振成像（MR）研究，探讨维生素C摄入量与OA之间的关系。
收集2003 - 2018年NHANES期间参与者的临床信息，并使用逻辑回归模型评估维生素C摄入量与OA风险之间的关系。在MR分析中，采用三种方法探讨维生素C摄入量与OA的因果关系。进行敏感性分析以验证MR研究的稳定性。
横断面研究共纳入31527名参与者，根据他们的维生素C摄入量水平将其分为低（<30.2毫克）、中（30.2 - 93.0毫克）和高（>93.0毫克）水平组。逻辑回归模型显示，维生素C摄入量与OA风险无关（>0.05）。MR研究的逆方差加权（IVW）方法显示维生素C摄入量与OA之间无因果关系（比值比=0.993，95%置信区间：0.901~1.095，P=0.882）。敏感性分析表明MR研究是可靠的。
我们的横断面研究和MR研究表明，维生素C摄入量与OA风险无关。未来需要更多研究来调查维生素C与OA之间的联系。
