基于美国国家健康与营养检查调查（NHANES）和孟德尔随机化研究的衰弱与骨关节炎之间的关联。
The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study.
作者信息
Huang Guoxin, Qian Da, Liu Ying, Qu Gaojing, Qian Yuanyuan, Pei Bin
机构信息
Department of Evidence-Based Medicine Center, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, China.
出版信息
Arch Med Sci. 2023 Aug 25;19(5):1545-1550. doi: 10.5114/aoms/171270. eCollection 2023.
INTRODUCTION
The aim of the study was to examine the association between frailty and osteoarthritis.
METHODS
We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two.
RESULTS
In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01-2.83).
CONCLUSIONS
There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.
引言
本研究的目的是探讨衰弱与骨关节炎之间的关联。
方法
我们在国家健康与营养检查调查中进行了一项横断面研究，同时使用逻辑回归来探讨两者之间的关联。采用孟德尔随机化（MR）研究来探索两者之间的因果关系。
结果
在横断面研究中，逻辑回归分析显示优势比（OR）（95%置信区间）值为1.07（1.05，1.08）。在MR研究中，逆方差加权（IVW）结果显示OR（95%置信区间）值为1.69（1.01 - 2.83）。
结论
衰弱与骨关节炎之间既存在相关性又存在因果关系，并且在骨关节炎方面，衰弱可能是比年龄更具潜在优势的反应指标。
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