Joy Elizabeth A, Briesacher Mark, Wiegand Benjamin
Lore, Department of Family & Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA (EAJ).
Lore, Park City, UT, USA (MB).
Am J Lifestyle Med. 2024 May 24;18(6):826-829. doi: 10.1177/15598276241256878. eCollection 2024 Nov-Dec.
Osteoarthritis, osteoporosis, and sarcopenia are prevalent musculoskeletal disorders that significantly impact the aging population's health and quality of life. Osteoarthritis, characterized by joint inflammation, leads to pain, stiffness, and reduced mobility. Osteoporosis, a condition marked by bone density loss, increases fracture susceptibility, especially in postmenopausal women and older adults. Sarcopenia, the age-related loss of muscle mass and function, contributes to frailty and an increased risk of falls. Combined, osteoarthritis, osteoporosis and sarcopenia constitute "Musculoskeletal Failure." These 3 conditions share common risk factors like aging, genetics, and hormonal changes, as well as unhealthy lifestyle behaviors resulting in systemic chronic inflammation. Healthy lifestyle behaviors, including regular physical activity and a nutritious diet across the lifespan play a crucial role in the prevention and management of musculoskeletal failure. Awareness of the relationship between lifestyle behaviors, systemic chronic inflammation and the development and progression of these 3 common conditions is a key step in prevention, early detection and are essential for addressing the complex interplay of these musculoskeletal disorders. As the global population ages, understanding and effectively preventing and managing osteoarthritis, osteoporosis, and sarcopenia become paramount for promoting healthy aging and mitigating the societal and economic burden associated with these conditions.
骨关节炎、骨质疏松症和肌肉减少症是常见的肌肉骨骼疾病，对老年人群的健康和生活质量有重大影响。以关节炎症为特征的骨关节炎会导致疼痛、僵硬和活动能力下降。骨质疏松症以骨密度降低为特征，会增加骨折易感性，尤其是在绝经后女性和老年人中。肌肉减少症是与年龄相关的肌肉质量和功能丧失，会导致身体虚弱和跌倒风险增加。骨关节炎、骨质疏松症和肌肉减少症共同构成了“肌肉骨骼功能衰退”。这三种情况有共同的风险因素，如衰老、遗传和激素变化，以及导致全身慢性炎症的不健康生活方式行为。健康的生活方式行为，包括一生中定期进行体育活动和保持营养均衡的饮食，在预防和管理肌肉骨骼功能衰退方面起着至关重要的作用。认识到生活方式行为、全身慢性炎症与这三种常见疾病的发生和发展之间的关系，是预防、早期发现的关键一步，对于应对这些肌肉骨骼疾病的复杂相互作用至关重要。随着全球人口老龄化，了解并有效预防和管理骨关节炎、骨质疏松症和肌肉减少症对于促进健康老龄化以及减轻与这些疾病相关的社会和经济负担至关重要。
