FitzSimmons J, Callahan C, Shanahan B, Jungkind D
J Reprod Med. 1986 Jan;31(1):19-22.
Chlamydia trachomatis is recognized as a common sexually transmitted cervical pathogen that may be transmitted to the neonate at delivery. Neonatal infection may be manifested as conjunctivitis, pneumonitis or both. Additionally, cervical infection may be related to premature rupture of the membranes and premature delivery. Women registering for prenatal care in the first half of pregnancy were cultured for Chlamydia to further define its role as a cause of perinatal complications and to evaluate a method of preventing transmission to the neonate. Positive cultures were obtained in 33 of 221 women evaluated (14.9%). No significant differences were found in pregnancy or neonatal complications between the groups with positive and negative cultures. Women with positive cultures were treated at 36 weeks' gestation with erythromycin; 18 received an adequate course of therapy. Of these 18, 16 returned with their infants four to eight weeks postpartum. No symptoms of conjunctivitis or pneumonitis were noted at that time, and cultures of the conjunctiva and nasopharynx were negative in all the infants. Thus, surveillance for Chlamydia and treatment late in pregnancy appear to have no adverse impact on pregnancy and effectively block vertical transmission of the organism.
沙眼衣原体被认为是一种常见的性传播宫颈病原体，在分娩时可能会传染给新生儿。新生儿感染可能表现为结膜炎、肺炎或两者皆有。此外，宫颈感染可能与胎膜早破和早产有关。对妊娠前半期登记进行产前检查的妇女进行沙眼衣原体培养，以进一步确定其作为围产期并发症病因的作用，并评估一种预防向新生儿传播的方法。在221名接受评估的妇女中，有33名培养结果呈阳性（14.9%）。培养结果阳性和阴性的两组在妊娠或新生儿并发症方面未发现显著差异。培养结果阳性的妇女在妊娠36周时接受红霉素治疗；18名妇女接受了足够疗程的治疗。在这18名妇女中，有16名在产后四至八周带着婴儿复诊。当时未发现结膜炎或肺炎症状，所有婴儿的结膜和鼻咽部培养结果均为阴性。因此，对沙眼衣原体的监测以及妊娠晚期的治疗似乎对妊娠没有不利影响，并且能有效阻断该病原体的垂直传播。
