Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.
College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Bone. 2022 Sep;162:116467. doi: 10.1016/j.bone.2022.116467. Epub 2022 Jun 7.
Sarcopenia refers to the age-related reduction in strength, muscle mass and functionality which increases the risk for falls, injuries and fractures. Sarcopenia is associated with other age-related conditions such as osteoporosis, frailty and cachexia. Identifying treatments to overcome sarcopenia and associated conditions is important from a global health perspective. There is evidence that creatine monohydrate supplementation, primarily when combined with resistance training, has favorable effects on indices of aging muscle and bone. These musculoskeletal benefits provide some rationale for creatine being a potential intervention for treating frailty and cachexia. The purposes of this narrative review are to update the collective body of research pertaining to the effects of creatine supplementation on indices of aging muscle and bone (including bone turnover markers) and present possible justification and rationale for its utilization in the treatment of frailty and cachexia in older adults.
肌肉减少症是指与年龄相关的力量、肌肉质量和功能下降，增加了跌倒、受伤和骨折的风险。肌肉减少症与其他与年龄相关的疾病有关，如骨质疏松症、虚弱和恶病质。从全球健康的角度来看，确定克服肌肉减少症和相关疾病的治疗方法非常重要。有证据表明，一水肌酸补充剂，主要与抗阻训练结合使用，对衰老肌肉和骨骼的指标有有利影响。这些肌肉骨骼益处为肌酸作为治疗虚弱和恶病质的潜在干预措施提供了一些依据。本综述的目的是更新与肌酸补充对衰老肌肉和骨骼（包括骨转换标志物）指标的影响相关的研究，为其在治疗老年人虚弱和恶病质中的应用提供可能的依据和理由。
