Lapshina A M, Bazarova E A, Przhialkovskaya E G, Khandaeva P M, Azizyan V N, Grigoriev A Yu, Ivashchenko O V, Tarbaeva N V, Belaya Zh E
Endocrinology Research Center.
Probl Endokrinol (Mosk). 2024 Nov 5;70(5):46-53. doi: 10.14341/probl13395.
Metastatic lesion of pituitary is a rare condition and is diagnosed in 1.8-4% of cases. Monitoring and treatment of such patients is a complex task and requires increased attention from a multidisciplinary team of specialists. The authors represent three patients with metastatic pituitary lesion who underwent neurosurgical treatment at the National Research Center of the National Research Institute of Endocrinology with subsequent pathomorphological confirmation of the diagnosis. The primary tumors were breast cancer, lung carcinoid, and clear cell kidney cancer. Two patients had distant metastases other than the pituitary gland. The clinical manifestation consisted in the appearance of symptoms of panhypopituitarism, chiasmal syndrome and mass effect in all cases. The follow-up period after surgical treatment was 0.25-2.5 years. Progression of the underlying disease was noted in two patients. One of them carried out stereotactic radiosurgical treatment and stereotactic oriented irradiation. One patient has a stable condition.
垂体转移瘤是一种罕见疾病,在1.8% - 4%的病例中被诊断出来。对此类患者的监测和治疗是一项复杂的任务,需要多学科专家团队给予更多关注。作者介绍了三名患有垂体转移瘤的患者,他们在国家内分泌研究所国家研究中心接受了神经外科治疗,随后经病理形态学确诊。原发肿瘤分别为乳腺癌、肺类癌和透明细胞肾癌。两名患者除垂体转移外还有远处转移。所有病例的临床表现均为全垂体功能减退、视交叉综合征和占位效应症状。手术治疗后的随访期为0.25 - 2.5年。两名患者出现了基础疾病进展。其中一名患者接受了立体定向放射外科治疗和立体定向定向照射。一名患者病情稳定。