[褪黑素单一疗法对处于标准条件下大鼠甲状腺激素和糖皮质激素水平影响的实验研究的荟萃分析]

[Meta-analysis of experimental studies of the effect of melatonin monotherapy on the levels of thyroid hormones and glucocorticoids in rats kept under standard condition].

作者信息

Kuzmenko N V, Tsyrlin V A, Pliss M G

机构信息

Almazov National Medical Research Centre; First Pavlov State Medical University of St. Petersburg.

Almazov National Medical Research Centre.

出版信息

Probl Endokrinol (Mosk). 2024 Nov 5;70(5):91-105. doi: 10.14341/probl13396.

DOI:10.14341/probl13396

PMID:39509641

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11610642/

Abstract

BACKGROUND

Melatonin is known to modulate circadian and seasonal rhythms in metabolism, reproduction, and behavior. However, the effect of exogenous melatonin supplementation on the functioning of the thyroid and adrenal glands in species without a clear seasonality in reproduction is still unclear.

AIM

Using a meta-analysis of publications, to investigate the effect of melatonin monotherapy on the concentrations of pituitary thyroid-stimulating hormone, thyroid hormones (TG), pituitary adrenocorticotropic hormone and corticosterone (CS) in rats kept under standard laboratory conditions.

MATERIALS AND METHODS

In our work, using the Review Manager 5.3 program, we conducted a meta-analysis of publications examining the effect of melatonin monotherapy on the functioning of the thyroid gland (22 papers) and adrenal glands (20 papers) in rats kept under standard conditions.

RESULTS

According to the results of our meta-analysis, the effects of melatonin on the levels of TG and CS depend on the dose and duration of therapy. A decrease in TG and CS was associated with therapy lasting no more than 4-5 weeks and with high doses of melatonin. An increase in CS and a trend toward increased TG levels were observed with longer therapy. However, a few studies have observed a decrease in TG with very long-term melatonin therapy (≥32 weeks). Among all TGs, total thyroxine (T4) showed maximum sensitivity to exogenous melatonin, which indicates the influence of melatonin on the secretory function of the thyroid gland. In addition, melatonin increased the relative weight of the adrenal glands. There was no convincing evidence that the effects of melatonin were influenced by the route and timing of administration, or the timing of blood sampling.

CONCLUSION

As a result, exogenous melatonin can modulate TG and CS levels, even in species without a clear seasonality in reproductive function.

摘要

背景

已知褪黑素可调节新陈代谢、生殖和行为中的昼夜节律和季节性节律。然而，在繁殖无明显季节性的物种中，外源性补充褪黑素对甲状腺和肾上腺功能的影响仍不清楚。

目的

通过对出版物的荟萃分析，研究褪黑素单一疗法对处于标准实验室条件下的大鼠垂体促甲状腺激素、甲状腺激素（TG）、垂体促肾上腺皮质激素和皮质酮（CS）浓度的影响。

材料和方法

在我们的研究中，使用Review Manager 5.3程序，对研究褪黑素单一疗法对处于标准条件下的大鼠甲状腺（22篇论文）和肾上腺（20篇论文）功能影响的出版物进行了荟萃分析。

结果

根据我们的荟萃分析结果，褪黑素对TG和CS水平的影响取决于治疗剂量和持续时间。TG和CS的降低与持续不超过4 - 5周的治疗以及高剂量褪黑素有关。随着治疗时间延长，观察到CS增加以及TG水平有升高趋势。然而，一些研究观察到长期（≥32周）褪黑素治疗后TG降低。在所有甲状腺激素中，总甲状腺素（T4）对外源性褪黑素表现出最大敏感性，这表明褪黑素对甲状腺分泌功能有影响。此外，褪黑素增加了肾上腺的相对重量。没有令人信服的证据表明褪黑素的作用受给药途径、给药时间或采血时间的影响。