Ievleva K D, Danusevich I N, Suturina L V
Scientific Centre for Family Health and Human Reproduction.
Probl Endokrinol (Mosk). 2024 Nov 5;70(5):106-114. doi: 10.14341/probl13397.
Leptin is not only the main regulator of energy balance, but also it affects the reproductive and immune systems. Leptin and its receptors are expressed in the endometrium and are actively involved in the embryo implantation. According to numerous studies, expression and level changes of leptin are associated with the inflammatory and autoimmune diseases, including endometriosis and chronic endometritis. Hyperplastic and inflammatory diseases of the uterus are accompanied by a violation of the receptivity of the endometrium due to the dysregulation of many factors involved in proliferation, vascularization and decidualization of cells. Activity of most of these factors is due to the leptin action, however, there are no studies of the direct effect of leptin in the pathogenesis of disorders of the endometrium in hyperplastic and inflammatory diseases.Thus, the purpose of this literature review was to describe the putative molecular mechanisms of the effect of leptin on the development of endometrial pathology.Literature search was carried out from 03/20/2023 to 05/11/2023 using scientific literature databases: NCBI PubMed, Google Scholar (foreign sources), Cyberleninka, Elibrary (domestic sources): references for the period 1995-2023 were analyzed. The following keywords were used for the search: leptin, endometrial dysfunction, endometrial receptivity, inflammation, pelvic inflammatory disease.
瘦素不仅是能量平衡的主要调节因子，还会影响生殖系统和免疫系统。瘦素及其受体在子宫内膜中表达，并积极参与胚胎着床过程。根据大量研究，瘦素的表达和水平变化与包括子宫内膜异位症和慢性子宫内膜炎在内的炎症性和自身免疫性疾病相关。子宫的增生性和炎症性疾病会因参与细胞增殖、血管生成和蜕膜化的多种因素失调而导致子宫内膜容受性受损。这些因素中的大多数活性都归因于瘦素的作用，然而，目前尚无关于瘦素在增生性和炎症性疾病中子宫内膜病变发病机制中直接作用的研究。因此，本综述的目的是描述瘦素影响子宫内膜病理发展的假定分子机制。使用科学文献数据库（NCBI PubMed、谷歌学术（国外来源）、Cyberleninka、电子图书馆（国内来源））于2023年3月20日至2023年5月11日进行文献检索：分析了1995年至2023年期间的参考文献。检索使用了以下关键词：瘦素、子宫内膜功能障碍、子宫内膜容受性、炎症、盆腔炎。
