炎症与自身免疫中的瘦素
Leptin in inflammation and autoimmunity.
作者信息
La Cava Antonio
机构信息
Department of Medicine, University of California Los Angeles, 1000 Veteran Ave. 32-59, Los Angeles, CA 90095, United States.
出版信息
Cytokine. 2017 Oct;98:51-58. doi: 10.1016/j.cyto.2016.10.011.
Abstract
After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response. This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses.
摘要
在被发现是代谢功能的关键调控因子之后，瘦素后来被广泛认为还具有其他功能，包括对先天性和适应性免疫反应的重要调节作用。这篇综述分析了瘦素在多种炎症性疾病（包括自身免疫性疾病）中的已知作用，以及这些知识如何有助于设计基于瘦素的调控策略，以帮助恢复异常的免疫反应。
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