痛风与肾结石之间的关联：孟德尔随机化研究及美国国家健康与营养检查调查（NHANES）的结果
Association between gout and kidney stone: results from mendelian randomization and the NHANES study.
作者信息
Jin Shengkai, Geng Haochen, Lu Yichen, Zhou Yuhua, Lv Jing, Fu Chaowei, Zhang Yuwei, Li Menglu, Feng Ninghan
机构信息
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Department of Urology, Jiangnan University Medical Center, Wuxi No. 2 People's Hospital, Wuxi, China.
出版信息
Front Genet. 2024 Oct 24;15:1417663. doi: 10.3389/fgene.2024.1417663. eCollection 2024.
BACKGROUND
Kidney stones are a common urologic disease with an increasing incidence year by year, and there are similar influences between gout status and kidney stone incidence. Therefore the contribution of gout status to the incidence of kidney stones is unclear. The aim of this study was to investigate the relationship between gout status and kidney stones and to further explore the causal relationship by Mendelian randomization (MR) analysis.
METHOD
An epidemiologic study of 49,693 participants in the 2009-2018 National Health and Nutrition Examination Survey (NHANES) was conducted to examine the association between the two. The causal relationship between gout status and kidney stones was assessed by Mendelian randomization analysis of data from the GWAS database.
RESULT
A total of 28,742 participants were included in the NHANES analysis. We found that gout status was associated with an increased risk of kidney stones [odds ratio (OR) = 1.45 (95%CI, 1.243-1.692); < 0.001]. In the MR analysis, we found a causal relationship between gout status and the risk of developing kidney stones (OR = 1.047, 95%CI, 1.011-1.085, = 0.009).
CONCLUSION
There may be an association between gout status and kidney stone risk. This finding requires further large-sample studies and adequate follow-up.
背景
肾结石是一种常见的泌尿系统疾病，发病率逐年上升，痛风状态与肾结石发病率之间存在相似的影响。因此，痛风状态对肾结石发病率的影响尚不清楚。本研究的目的是探讨痛风状态与肾结石之间的关系，并通过孟德尔随机化（MR）分析进一步探究因果关系。
方法
对2009 - 2018年美国国家健康与营养检查调查（NHANES）中的49693名参与者进行了一项流行病学研究，以检验两者之间的关联。通过对GWAS数据库的数据进行孟德尔随机化分析，评估痛风状态与肾结石之间的因果关系。
结果
NHANES分析共纳入28742名参与者。我们发现痛风状态与肾结石风险增加相关[比值比（OR）= 1.45（95%CI，1.243 - 1.692）；P < 0.001]。在MR分析中，我们发现痛风状态与患肾结石风险之间存在因果关系（OR = 1.047，95%CI，1.011 - 1.085，P = 0.009）。
结论
痛风状态与肾结石风险之间可能存在关联。这一发现需要进一步的大样本研究和充分的随访。
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