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乍得人畜中寨卡病毒传播的证据。

Evidence of Zika virus circulation in human and livestock in Chad.

作者信息

Chable de la Héronnière François, Barthelemy Jonathan, Dzomo Guy R Takoudjou, Abdelrazakh Fatima, Djarma Oumaima, Auguste Lucas, Fouda Abderrazzack A, Adawaye Chatté, Andreoletti Laurent, Abakar Mahamat Fayiz, Simonin Yannick, Salinas Sara, Mennechet Franck Jd

机构信息

Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), INSERM U1058, University of Montpellier, French Blood Establishment (EFS), Montpellier, France.

University Hospital Complex "Le Bon Samaritain", N'Djamena, Chad.

出版信息

Virus Res. 2024 Dec;350:199492. doi: 10.1016/j.virusres.2024.199492. Epub 2024 Nov 20.

DOI:10.1016/j.virusres.2024.199492
PMID:39521251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736396/
Abstract

Zika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock in Chad using a seroneutralization assay that ensures high specificity level. In this retrospective serological serosurveillance investigation, we estimated the neutralizing seroprevalence to be approximately 26 % (18/69) in healthy Chadian participants and 17 % (16/94) in HIV-infected individuals, with no statistical difference between these two subgroups or genders. In addition, we found an overall ZIKV prevalence of 14 % (8/59) in small ruminants (sheep and goats) living in the Lake Chad Basin area, demonstrating virus circulation in animals. Our pilot study shows for the first-time evidence of ZIKV circulation in humans and in livestock in Chad in close interaction with humans, and highlights the main challenges associated with this virus in Sahelian areas.

摘要

寨卡病毒（ZIKV）是一个全球性的重大公共卫生问题。在多次疫情爆发报告之后，这种黄病毒科病毒在萨赫勒地区目前的感染范围仍有待探索。我们使用确保高特异性水平的血清中和试验，调查了乍得普通人群、艾滋病毒感染者和牲畜中抗寨卡病毒中和抗体的流行情况。在这项回顾性血清学血清监测调查中，我们估计乍得健康参与者的中和血清阳性率约为26%（18/69），艾滋病毒感染者为17%（16/94），这两个亚组或不同性别之间无统计学差异。此外，我们发现生活在乍得湖流域地区的小型反刍动物（绵羊和山羊）中寨卡病毒总体流行率为14%（8/59），表明该病毒在动物中传播。我们的初步研究首次显示了寨卡病毒在乍得的人类和与人类密切接触的牲畜中传播的证据，并突出了萨赫勒地区与这种病毒相关的主要挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4a/11736396/5f529ad992cf/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4a/11736396/4b2bf7b8f1e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4a/11736396/5f529ad992cf/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4a/11736396/4b2bf7b8f1e1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b4a/11736396/5f529ad992cf/gr2.jpg

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本文引用的文献

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Detection and persistence of Zika virus in body fluids and associated factors: a prospective cohort study.体液中寨卡病毒的检测和持续存在及其相关因素：一项前瞻性队列研究。
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High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar.马达加斯加 HIV 感染者（PLWHIV）中多种虫媒病毒 IgG 抗体的高血清阳性率。
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Antibody seropositivity and endemicity of chikungunya and Zika viruses in Nigeria.
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Seroprevalence of Chikungunya and Zika virus in nonhuman primates: A systematic review and meta-analysis.非人灵长类动物中基孔肯雅病毒和寨卡病毒的血清流行率：一项系统评价和荟萃分析。
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Zika Virus Immunoglobulin G Seroprevalence among Young Adults Living with HIV or without HIV in Thailand from 1997 to 2017.1997 年至 2017 年期间，泰国生活的 HIV 感染者和非感染者的年轻成年人中寨卡病毒 IgG 血清流行率。
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